Results 11 to 20 of about 14,911 (253)

Vulneración del principio de igualdad en el régimen especial de contratación administrativa de servicios – CAS en sede central Essalud 2020 [PDF]

open access: yes, 2022
El objetivo de estudio en la presente investigación fue analizar la “Vulneración del Principio de Igualdad en el Régimen Especial de Contratación Administrativa de Servicios – CAS en la Sede Central EsSalud 2020”.
Morales Sosa, Amelia
core  

El régimen especial de pensiones de la Fuerza Pública: algunas reflexiones respecto a su carácter especial [PDF]

open access: yes, 2020
Artículo de investigaciónPreviendo la existencia de un régimen pensional de carácter especial para los miembros de la Fuerza Pública, el actual documento indaga sobre la eventual vulneración de los principios generales que rigen el Sistema General de ...
Soler-Ruiz, Angela Viviana
core  

Régimen especial fiscal de las operaciones de reestructuración empresarial [PDF]

open access: yes, 2021
El presente trabajo trata sobre el régimen especial fiscal de las distintas operaciones de reestructuración empresarial que recoge la Ley de Impuestos Sobre Sociedades.
Marco Pueyo, Clara   +1 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Régimen tributario especial en Colombia

open access: yes, 2021
El régimen tributario especial cobija a empresas que cumplen con 3 requisitos específicos explicados a lo largo de este documento. Este régimen propone beneficios tributarios para quienes cumplen estos requisitos al reducir en 20% el valor del impuesto ...
Gómez Moncada, María José   +1 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

EL RÉGIMEN ESPECIAL SOCIETARIO EN COLOMBIA

open access: yes, 2021
Se realiza un estudio teórico y un análisis práctico sobre un tipo de sociedad que en Colombia se crea por una o varias personas naturales o jurídicas, con el fin de realizar actividades en beneficio de sus asociados, terceras personas o la comunidad en ...
Sandoval Ortega, Ernesto   +1 more
core   +1 more source

Remarkable Recovery After Delayed High‐Dose Methylprednisolone in a Rare Case of Penetrating Spinal Cord Injury

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Traumatic spinal cord injury (TSCI) caused by sharp‐force penetration is exceptionally rare, and the use of high‐dose methylprednisolone (MP) remains highly controversial, especially beyond the conventional 8‐h treatment window. This case report describes a 30‐year‐old male with acute incomplete TSCI following a knife stab wound to the right ...
Honghong Wang   +5 more
wiley   +1 more source

Marked Long‐Term Improvement in Lung Function in Melanoma Differentiation–Associated Protein 5 Antibody–Positive Dermatomyositis Patients: Experience of a Single‐Center Longitudinal Cohort in North America

open access: yesArthritis Care &Research, EarlyView.
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Jenice X. Cheah   +8 more
wiley   +1 more source

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