Results 71 to 80 of about 543,991 (236)

A Mussel‐Inspired Bioadhesive Patch to Selectively Kill Glioblastoma Cells

Advanced Science, EarlyView.
An innovative mussel‐inspired bioadhesive patch has been developed for post‐surgical glioblastoma treatment. The patch, which adheres strongly in biological environments, releases a localized treatment. This treatment, acting via reactive oxygen species, shows specific toxicity to glioblastoma cells.
Jose Bolaños‐Cardet, Sara Pugliese, Jordi Bruna, Daniel Ruiz‐Molina, Salvio Suárez‐García, Victor J. Yuste   +5 more
wiley   +1 more source

Generalidades del régimen del crédito sindicado: mención especial al derecho inglés

Revista de Derecho Privado (Bogota. 1997), 2012
El uso del crédito sindicado ha proliferado como consecuencia de las grandes sumas requeridas por los clientes de la banca comercial. Sin embargo, la limitación de recursos y la necesidad de distribuir el riesgo de incumplimiento entre varios acreedores ...
Ligia Catherine Arias Barrera
doaj   +2 more sources

Dipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes

Advanced Science, EarlyView.
By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.
Jiale Dong, Ting Guo, Yi Huang, Yangchun Ma, Weijin Chen, Jie Xue, Jun Jiang, Enhui Dong, Yue Kong, Hang Ding, Wenlong Zhang, Shutao Ma   +11 more
wiley   +1 more source

Impact of weather-climatic parameters on agricultural productions in Dolj County/Romania [PDF]

, 2012
El impacto de los parámetros climáticos para el tiempo en producciones agrícolas en el Condado de Dolj. Para una evaluación objetiva de las condiciones agrometeorologicas existentes en el área, en términos de su potencial agroproductivo, aparecio ...
FLORINA CRISTINA ROSCA
core  

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

ALTERNATIVAS DEL REGIMEN ESPECIAL BALEAR.

Revista de Estudios de la Administración Local y Autonómica, 1976
Francisco J. Lliset Borrell
doaj   +3 more sources

La Intervención socio-educativa en los centros de menores : especial referencia al internamiento en Régimen Terapéutico [PDF]

, 2015
Treball Final de Grau en Criminologia i Seguretat. Codi: CS1044. Curs: 2014/2015Este trabajo pretende realizar una visión generalizada de la ley penal del menor.
López Boils, Lidia
core  

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source

In Situ Lipoprotein‐seeking Dye for in Vivo Real‐Time Imaging of Lipid Dysregulation Diseases

Advanced Science, EarlyView.
This study develops lipoprotein‐seeking NIR‐II dyes that specifically bind circulating lipoproteins. These dyes form ultra‐stable complexes with endogenous lipoprotein, enabling real‐time, high‐contrast imaging of fatty liver and atherosclerotic plaques. Tunable binding kinetics allow customized imaging windows.
Yijing Du, Zetao Dang, Baofeng Xu, Jiajun Xu, Dan Wang, Yuewei Zhang, Shoujun Zhu   +6 more
wiley   +1 more source

Conocimientos tradicionales sobre recursos genéticos : ¿bien jurídico global? [PDF]

, 2012
¿En razón de que unos conocimientos calificados como tradicionales y particularmente aquellos que versan sobre recursos genéticos se han elevado a toda una categoría jurídica del lenguaje internacional, en especial de aquel que se mueve en el campo de la
Clavero Salvador, Bartolomé
core   +2 more sources