Results 211 to 220 of about 669,721 (248)

Mycolicibacterium mageritense Bacteremia Following Partial Nephrectomy: A Case Report. [PDF]

Cureus
Castro R.
europepmc   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Implication of Post-Induction Minimal Residual Disease in the Management of Pediatric Acute Lymphoblastic Leukemia in a Resource-Limited Setting. [PDF]

Cureus
Mushtaq W, Anwar S, Ahmad S, Faizan M, Gull S, Gull A.   +5 more
europepmc   +1 more source

Pathogen‐Centric Activation of an Azoreductase‐Responsive Antibody‐Antibiotic Conjugate for the Targeted Eradication of MRSA

Advanced Science, EarlyView.
A pathogen‐centric antibody‐antibiotic conjugate (AZO‐AAC) releases antibiotics via bacterial azoreductase, independent of host‐lysosomal function. This mechanism achieves nanomolar eradication of both planktonic and intracellular methicillin‐resistant Staphylococcus aureus (MRSA).
Qi Cheng, Lianqi Liu, Chenghua Liu, Fei Xie, Jingwen Dong, Xiaoyu Qin, Shunxiang Huang, Xian Li, Xingyuan Kou, Hongbin Deng, Jiannan Feng, Wu Zhong, Dian Xiao, Xinbo Zhou   +13 more
wiley   +1 more source

Pazopanib combined with doxorubicin and cisplatin in recurrent osteosarcoma: A retrospective cohort study. [PDF]

Medicine (Baltimore)
Cai WL, Cheng M, Sun ZW, Fang M, Yan WJ, Chen XS, Jiao GL.   +6 more
europepmc   +1 more source

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source

Medication adherence rates in patients with ocular inflammatory disease. [PDF]

Front Med (Lausanne)
Chew ZRJ, Cheng LC, Agrawal R, Ho SL, Wei X, Thng ZX.   +5 more
europepmc   +1 more source

Optimizing safety and efficacy in radiotherapy for external auditory canal cancer. [PDF]

Oncol Lett
Imai Y, Takaoka T, Tomita N, Kuno M, Miyakawa A, Sugie C, Otsuka S, Uchiyama K, Okazaki D, Niwa M, Torii A, Kita N, Oguri M, Takano S, Matoba T, Kawakita D, Iwasaki S, Hiwatashi A.   +17 more
europepmc   +1 more source

In Regard to Prabhu et al. [PDF]

Adv Radiat Oncol
Marwaha AS, Shepard MJ, Wegner RE.
europepmc   +1 more source

Endoscopic resection as a "resect-to-confirm" strategy after neoadjuvant downstaging for remnant gastric cancer. [PDF]

Endoscopy
Zuo X, Chen Q, Du C, Shao Q, Zhou J, Wang Z, Linghu E.   +6 more
europepmc   +1 more source