Results 141 to 150 of about 45,350 (227)

In Silico Decoding of Nonsteroidal Mineralocorticoid Receptor Antagonist Binding: Implications for Drug Design. [PDF]

J Chem Inf Model
Pérez-Gordillo F, Carpio LE, Alvarez de la Rosa D, Martín-Martínez M.   +3 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Structural dynamics of IRE1 and its interaction with unfolded peptides. [PDF]

Elife
Spinetti E, Ścibisz G, Karagöz GE, Covino R.   +3 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Detecção de réplicas de sítios web usando aprendizado semissupervisionado baseado em maximização de expectativas

, 2014
The Web contains a vast repository of information. According to the literature about 29% of this repository contains duplicate content. Duplication of content may occur within a single web site (intra-site) or between different web sites (inter-site ...
Cristiano Rodrigues de Carvalho
core  

From Lipid Composition to Electroporation: Mechanical Encoding of Barrier Resilience in Stratum Corneum Membranes. [PDF]

ACS Omega
Machado NCF, García NA, Anguita-Ortiz N, Ruano L, Nogueira JJ, Martinho HDS.   +5 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Desenvolvimento de caixa para réplicas de urnas arqueológicas: DOI: https://doi.org/10.29327/5457226.1-279

O presente artigo é parte de uma dissertação de mestrado em andamento, que se propõe a contribuir com a preservação de patrimônio nacional por meio de tecnologias contemporâneas.
Sheila Cordeiro Mota, José Carlos Calado Sales Junior, Anna Tainah Tarrio de Paula   +2 more
core  

Rapid Fabrication of Bioinspired Compound-Eye Array with Hydrophobicity and Antireflectivity. [PDF]

Biomimetics (Basel)
Yao Z, Yuan L, Lu J, Huang G, Li Z, Li Y, Xie H, Zhang G.   +7 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source