Results 231 to 240 of about 112,087 (240)

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Fabrication of tunable Large-Area Moth-Eye nanostructures for antireflection and hydrophobicity via anodic aluminum oxide templates and nanoimprint lithography. [PDF]

Discov Nano
Hung HH, Lin SK, Lin RX, Huang TN, Wu CC.   +4 more
europepmc   +1 more source

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source

Simulated Solute Tempering 2: An Efficient and Practical Approach to Protein Conformational Sampling and Binding Events. [PDF]

J Chem Theory Comput
Stratmann D, Moroy G, Tuffery P, Murail S.   +3 more
europepmc   +1 more source

Chiral Ligand-Protected Gold Nanoclusters as Biosensors for Small Chiral Biomolecules: A Computational Study. [PDF]

ACS Nano
Fallah Z, Malola S, Matus MF, Häkkinen H.   +3 more
europepmc   +1 more source

Transient formation of supramolecular complexes between hyaluronan and oligopeptides at submicromolar concentration. [PDF]

Commun Chem
Riopedre-Fernandez M, Chu B, Kuffel A, Marchioro A, Biriukov D, Martinez-Seara H.   +5 more
europepmc   +1 more source

Impact of Taper Design on Cleaning Efficacy, Stress Generation, and Irrigant Performance: A Combined Experimental, Finite Element Analysis, and Computational Fluid Dynamics Assessment. [PDF]

Dent J (Basel)
Maqueda CV, Navarrete N, Ramírez-Muñoz A, Martín-Díaz A, de Gregorio C, Aranguren J, Malvicini G, Grandini S, Vieira GCS, Pérez AR.   +9 more
europepmc   +1 more source

HU Searches and Binds Specific DNA via a Multistep Process Combining Weak Electrostatic Binding, Protein Reorientation, and DNA Flexibility. [PDF]

JACS Au
Chan EW, Leake MC, Noy A.
europepmc   +1 more source

The effect of ionic strength on PETase enzymes: An experimental and computational study. [PDF]

Protein Sci
Berselli A, Carletti A, Menziani MC, Bhattacharya S, Castagna R, Parisini E, di Rocco G, Muniz-Miranda F.   +7 more
europepmc   +1 more source