Results 51 to 60 of about 55,477 (217)

A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control

Advanced Science, EarlyView.
Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias, Carmen Domínguez‐Alonso, Ivana Zagorac, Antonio Tapia‐Galisteo, Eva García‐Veros, Laura Rubio‐Pérez, Marina Gómez‐Rosel, Patricia Fuentes, Patricia Hernández‐López, Óscar Aguilar‐Sopeña, Laura Almagro‐Puente, Sonia Martínez‐González, Lucía Cañizares‐Moscato, María Rivas‐Sánchez, Belén Blanco, Ángel Ramírez‐Fernández, Laura Díez‐Alonso, Carmen Blanco‐Aparicio, Javier Arroyo‐Ródenas, Jorge Martínez‐Torrecuadrada, María L. Toribio, Pedro Roda‐Navarro, Anaïs Jiménez‐Reinoso, Luis Álvarez‐Vallina   +23 more
wiley   +1 more source

Residuos de agroquímicos en sedimentos de ríos, Poás, Costa Rica

Agronomía Costarricense, 2008
Se analizó la presencia y distribución de agroquímicos organofosforados y organoclorados en los sedimentos de 3 ríos localizados en un área de producción de ornamentales en el cantón de Poás, Alajuela, Costa Rica.
Federico Masís, Juan Valdez, Tatiana Coto, Sandra León   +3 more
doaj  

Análisis etnohistórico de la complejidad social del bajo delta del río Colorado con base en documentos misionales de fines del siglo XVII y del XVIII.

Revista Atlántica-Mediterránea de Prehistoria y Arqueología Social, 2014
El bajo delta del Colorado es, con base en el analisis etnohistorico de documentos virreinales de finales del s. XVII y del s. XVIII, el area nuclear de una region de intensa efervescencia interetnica. En esta dinamica social estaban integradas todas las sociedades del tercio norte del Desierto de Sonora, tanto las sedentarias como aquellas que basan ...
openaire   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Breaking the Durability–Power Trade‐Off: Boron‐Directed Faceted O3 Cathodes for High‐Rate Sodium‐Ion Batteries

Advanced Energy Materials, EarlyView.
Boron‐oxide‐assisted particle engineering stabilizes O3‐type layered cathodes for sodium‐ion batteries by mitigating phase transitions and lattice strain. Acting as flux and structural modifier, boron forms submicron hexagonal platelets with (003) facets and expanded Na‐layer spacing, enabling rapid Na⁺ diffusion and mechanical resilience.
Tengfei Song, Alexis Manche, Dongrui Xie, Bowen Liu, Chenglong Wu, Bo Dong, Reda Malakauskaite, Manoj Ovhal, David O. Scanlon, Emma Kendrick   +9 more
wiley   +1 more source

Periodos oscuros e investigación histórica: una aproximación desde la periferia; el modo de producción feudal en el área minera de Río Tinto

Revista Atlántica-Mediterránea de Prehistoria y Arqueología Social, 2000
En las lineas que siguen abordamos un asunto ya viejo y largamente debatido, la existencia o no de Feudalismo en la Peninsula Iberica, desde una perspectiva local cenida a un territorio concreto pero claramente ejemplificador del condicionamiento impuesto por estudios historicos vacios e improductivos en lo que se refiere a su sustento empirico y ...
openaire   +1 more source

Balancing Exploration and Exploitation Through a Sequential Hybrid of Roach Infestation and Mayfly Algorithms for Constrained Engineering Design Optimization

AI &Innovation, EarlyView.
ABSTRACT Maintaining an effective balance between exploration and exploitation is essential during optimization processes, from mathematical functions to more complex problems such as constrained engineering design optimization, particularly when addressing highly nonlinear issues with numerous local optima and strict feasibility requirements.
Enrique Lizárraga, Fevrier Valdez, Oscar Castillo, Patricia Melin   +3 more
wiley   +1 more source

Fishes of the Tambopata-Candamo reserved zone, southeastern Perú.

Revista Peruana de Biología, 2014
A list of fishes found in the Tambopata-Candamo Reserved Zone, Southeastern Peru is presented herein. This fauna includes 36 families, 138 genera and 232 species; characiforms and siluriforms are the main groups, dominating all environments.
Fonchii Chang
doaj   +1 more source

COX14 Variants Are Associated With Mitochondrial Complex IV Deficiency Nuclear Type 10 (MC4DN10)

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT COX14 encodes a transmembrane protein essential for cytochrome c oxidase (COX) complex assembly. A homozygous missense variant in COX14 was reported in three siblings from a single consanguineous family with severe, fatal infantile mitochondrial complex IV deficiency nuclear type 10 (MC4DN10; MIM# 619053).
Elias K. Awad, Emily Waskow, Hari Tunuguntla, Joseph Spinner, Hanna J. Tadros, Lisa T. Emrick, Daniel G. Calame, Fernando Scaglia   +7 more
wiley   +1 more source

Análisis de tendencias e índices de extremos hidroclimáticos en el nordeste antioqueño a partir de registros históricos

TecnoLógicas
El cambio climático modifica la hidroclimatología global y aumenta los riesgos sociales, ambientales y económicos. En Colombia, la variabilidad climática y la falta de datos dificultan su análisis y predicción. El objetivo de este estudio fue evaluar las
Lilia María Marín-Zapata, Alejandro Builes-Jaramillo, Hernán D. Salas, Carlos Arturo Hoyos-Restrepo   +3 more
doaj   +1 more source