Results 51 to 60 of about 4,089 (272)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Weighted Hardy operators in local generalized Orlicz-Morrey spaces

Karpatsʹkì Matematičnì Publìkacìï, 2021
In this paper, we find sufficient conditions on general Young functions $(\Phi, \Psi)$ and the functions $(\varphi_1,\varphi_2)$ ensuring that the weighted Hardy operators $A_\omega^\alpha$ and ${\mathcal A}_\omega^\alpha$ are of strong type from a local
C. Aykol, Z.O. Azizova, J.J. Hasanov
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Existence and uniqueness of functional differential equations with n delay [PDF]

, 2017
In this paper we give a necessary and suffcient conditions for the existence and uniqueness of periodic solutions of functional differential equations with n delay d dt x(t) = Ax(t) + n j=1 Bx(t -- r j) + f (t).
Rachid, Bahloul
core   +1 more source

Criterion of (L^p, L^r) boundedness for a class of multilinear oscillatory singular integrals [PDF]

Nagoya Mathematical Journal, 1998
Abstract.In this paper, we consider a kind of multilinear operators related to oscillatory singular integrals with rough kernels and give a criterion of certain boundedness for this kind of operators.
Chen, Wengu, Hu, Guoen, Lu, Shanzhen
openaire   +3 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

On M∗-Irresolute Topological Rings

International Journal of Analysis and Applications, 2023
The main aim of this paper is to introduce and study the new notions namely M∗-irresolute topological rings and M∗-irresolute topological R-modules by virtue of M∗-open sets.
Shallu Sharma, Naresh Digra, Pooja Saproo, Tsering Landol   +3 more
doaj   +1 more source

On the $\mathcal{R}$-boundedness of solution operator families for two-phase Stokes resolvent equations

Differential and Integral Equations, 2017
The aim of this paper is to show the existence of $\mathcal{R}$-bounded solution operator families for two-phase Stokes resolvent equations in $\dot = _+\cup _-$, where $ _\pm$ are uniform $W_r^{2-1/r}$ domains of $N$-dimensional Euclidean space $\mathbf{R}^N$ ($N\geq 2 ...
Maryani, Sri, Saito, Hirokazu
openaire   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source