Results 81 to 90 of about 4,089 (272)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Integral transform with the extended generalized Mittag‐Leffler function
Mathematical Modelling and Analysis, 2006 The paper is devoted to the study of the integral transform containing the special function å((á, â) n ;z) generalizing the Mittag‐Leffler type function in the space £v,r (1 ≤ r ≤ 8, í ∈ R) of Lebesgue measurable functions on R+ = (0,+8) such ...
A. A. Kilbas, A. A. Koroleva
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Hardy operators and commutators on generalized central function spaces
Electronic Journal of Differential EquationsIn this article, we study the boundedness of operators of Hardy type on generalized central function spaces, such as the generalized central Hardy space $\mathbf{HA}^{p,r}_\varphi(\mathbb{R}^n)$, the generalized central Morrey space $\dot{\mathbf{M}}^{p ...
Le Trung Nghia
doaj
Analytic vector-functions in the unit ball having bounded $\mathbf{L}$-index in joint variables
Karpatsʹkì Matematičnì Publìkacìï, 2019 In this paper, we consider a class of vector-functions, which are analytic in the unit ball. For this class of functions there is introduced a concept of boundedness of $\mathbf{L}$-index in joint variables, where $\mathbf{L}=(l_1,l_2): \mathbb{B}^2\to ...
V.P. Baksa
doaj +1 more source
R-Boundedness versus γ-boundedness
, 2016 Analysis
Kwapien, Stanislaw +2 more
openaire +2 more sources