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The molecular nature of R-factors
Journal of Molecular Biology, 1966The acquisition of infectious multiple drug resistance factors by Proteus mirabilis was correlated with the addition of one or more physically recognizable, native, satellite DNA fractions. The spontaneous loss of one or more drug resistance characteristics carried by R-factors was correlated with either an apparent loss of particular density regions
Stanley Falkow +3 more
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Molecular and General Genetics MGG, 1972
Eight R factors are described which fall into four compatibility groups, distinct from previously described F-like and I-like groups. E. coli K12 carrying one of these factors, TP114, supports multiplication of the I-specific phage If1. However, TP114 is fully compatible with the I-like factor T-Δ and with all the other R factors described in this ...
N D, Grindley +2 more
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Eight R factors are described which fall into four compatibility groups, distinct from previously described F-like and I-like groups. E. coli K12 carrying one of these factors, TP114, supports multiplication of the I-specific phage If1. However, TP114 is fully compatible with the I-like factor T-Δ and with all the other R factors described in this ...
N D, Grindley +2 more
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R Factors for Aminoglycoside Antibiotics
Journal of Infectious Diseases, 1969The definition of R factors by Japanese scientists 10 years ago opened a new chapter in the saga of antibiotic resistance among enteric bacteria [1]. This package of extrachromosomal genes, comprised of the resistance determinants, which mediate resistance to a variety of environmental hazards, and the resistance transfer factors (RTF), which mediate ...
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Cancer and the unavoidable R factor
Science, 2017Cancer Etiology Most textbooks attribute cancer-causing mutations to two major sources: inherited and environmental factors. A recent study highlighted the prominent role in cancer of replicative (R) mutations that arise from a third source: unavoidable errors associated with DNA replication. Tomasetti et al.
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Independence number, connectivity, and r‐factors
Journal of Graph Theory, 1989AbstractWe show that if r ⩾ 1 is an odd integer and G is a graph with |V(G)| even such that k(G) ⩾ (r + 1)2/2 and (r + 1)2α(G) ⩽ 4rk(G), then G has an r‐factor; if r ⩾ 2 is even and G is a graph with k(G) ⩾ r(r + 2)/2 and (r + 2)α(G) ⩽ 4k(G), then G has an r‐factor (where k(G) and α(G) denote the connectivity and the independence number of G ...
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New England Journal of Medicine, 1970
Abstract Although the therapeutic use of antibiotics favors the selection of bacteria that contain R factor, it does not necessarily follow that man-made antibiotics have induced the evolution of R factor. We have obtained evidence that R factor evolved before the advent of the antibiotic era.
C E, Davis, J, Anandan
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Abstract Although the therapeutic use of antibiotics favors the selection of bacteria that contain R factor, it does not necessarily follow that man-made antibiotics have induced the evolution of R factor. We have obtained evidence that R factor evolved before the advent of the antibiotic era.
C E, Davis, J, Anandan
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A reexamination of the WAIS—R factor structure.
Psychological Assessment: A Journal of Consulting and Clinical Psychology, 1990We performed a series of restricted factor analyses on the 9 cohorts of the WAIS-R standardization sample in an effort to investigate the structure of this instrument. Several indices of fit were used including (a) the likelihood ratio test statistic, chisquare; (b) the LISREL Goodness of Fit Index; (c) the normed-fit index, with both a null and ...
Niels G. Waller, Irwin D. Waldman
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Inhibition of R-factor transfer by levallorphan
Biochemical and Biophysical Research Communications, 1971Abstract The transfer of an R-factor from Proteus Rettgeri to Escherichia coli W 677 was strongly inhibited by levallorphan at concentrations which do not affect growth of either the donor or the recipient cells. The effect is not due to the transfer of the episom itself but to inhibition of mating-pair formation.
R, Löser +2 more
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Journal of Infectious Diseases, 1971
antimicrobial agents. Separate genetic determinants, grouped in various patterns on individual R factors, specify resistance to sulfonamides, penicillins and cephalosporins, chloramphenicol, tetracyclines, the kanamycin-neomycin group of antibiotics, and streptomycin, together with some related aminoglycoside antibiotics [1-3].
S A, Kabins, M V, Panse, S, Cohen
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antimicrobial agents. Separate genetic determinants, grouped in various patterns on individual R factors, specify resistance to sulfonamides, penicillins and cephalosporins, chloramphenicol, tetracyclines, the kanamycin-neomycin group of antibiotics, and streptomycin, together with some related aminoglycoside antibiotics [1-3].
S A, Kabins, M V, Panse, S, Cohen
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