Results 51 to 60 of about 15,790,043 (329)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Instalando R Studio macOs

, 2023
Guias rápidas para ...
Osorio Colonia, Juan Camilo, Vásquez, Angie Natalia, Loaiza, Juan Guillermo   +2 more
openaire   +1 more source

System Usability Scale Benchmarking for Digital Health Apps: Meta-analysis

JMIR mHealth and uHealth, 2022
Background The System Usability Scale (SUS) is a widely used scale that has been used to quantify the usability of many software and hardware products.
Maciej Hyzy, Raymond R. Bond, M. Mulvenna, Lu Bai, Alan J. Dix, Simon Leigh, S. Hunt   +6 more
semanticscholar   +1 more source

Aplicación de un algoritmo genético que incorpora lógica difusa para la minimización del tiempo del proceso de corte de diferentes tipos de materia prima para la empresa confecciones taller 84 [PDF]

, 2015
En el trabajo de grado se utilizó la aplicación de un algoritmo genético para la minimización del tiempo de proceso de corte para una empresa que confecciona dotaciones industriales.
Duarte Arias, Andrés Felipe, Orozco Ahumada, Carlos Fernando   +1 more
core  

Radiation protection considerations on radon and building materials radioactivity in Near Zero Energy Buildings [PDF]

, 2017
Recent updates of the E.U. Basic Safety Standards, stated in the Council Directive 2013/59/EURATOM, are focusing on risks related to radon gas concentration inside dwellings and working places, as well as radioactivity of building materials.
Franci, Daniele, Gandolfo, Giada, Lepore, Luigi, Pepperosa, Andrea, Remetti, Romolo   +4 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Migliorare Autostima e Autoefficacia per ridurre lo Stress attraverso la tecnica energetico-meditativa detta Espansione di Coscienza del Metodo Cosmo. Lo studio si è svolto su 100 corsisti

Scienze Biofisiche
L’espansione di Coscienza è una tecnica bioenergetica del Metodo Cosmo (ampliamento del più conosciuto Metodo Summa Aurea di cui è erede) (Fabbroni R., Columbano T., 2024) che è in grado di agire a livello Psicologico, a livello mentale, a livello ...
A. Sanna, Teresa Columbano, Katya Ondradu, Mariangela Puddori, C. Molinari, Melissa Barontini, Giuliana Cittanti   +6 more
semanticscholar   +1 more source

Interspecific differences in the larval performance of Pieris butterflies (Lepidoptera: Pieridae) are associated with differences in the glucosinolate profiles of host plants

, 2019
The tremendous diversity of plants and herbivores has arisen from a coevolutionary relationship characterized by plant defense and herbivore counter adaptation. Pierid butterfly species feed on Brassicales plants that produce glucosinolates as a chemical
Hirai, M., Kuroda, S., Murakami, M., Okamura, Y., Sato, A., Sawada, Y., Tsuzuki, N.   +6 more
core   +1 more source

The effect of adding comorbidities to current centers for disease control and prevention central-line–associated bloodstream infection risk-adjustment methodology [PDF]

, 2017
BACKGROUNDRisk adjustment is needed to fairly compare central-line–associated bloodstream infection (CLABSI) rates between hospitals. Until 2017, the Centers for Disease Control and Prevention (CDC) methodology adjusted CLABSI rates only by type of ...
Anderson, Deverick J, Harris, Anthony D, Jackson, Sarah S, Kaye, Keith S, Leekha, Surbhi, Lowe, Timothy J, Magder, Laurence S, Pineles, Lisa, Stafford, Kristen, Thom, Kerri, Trick, William E, Woeltje, Keith F   +11 more
core   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source