Results 51 to 60 of about 12,108,065 (316)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The Rowan Tree Church Annual Report for 1993-1994 [PDF]
, 1994 This digital asset was created from the original digital scans by Rev. Paul V. Beyerl and provided to the Valdosta State University, Archives & Special Collections to be part of their Rowan Tree Church Periodicals Collection of the New Age Movements ...
Rowan Tree Church
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Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Life cycle assessment of nuclear power in France: EDF case study
EPJ Nuclear Sciences & TechnologiesThe French electricity mix is dominated by nuclear power, representing 69% of the power generation in 2021, and further development of nuclear power for electricity is expected.
Le-Boulch Denis +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source
Rowan Tree Church. Annual Report, Hallows 1983-1984 ce [PDF]
, 1984 The Rowan Tree Church is an earth-based religion founded by Rev. Paul Beyerl, a Third Degree Initiate in the Alexandrian Tradition of Wicca, and incorporated on February 4, 1980 in Minneapolis, Minnesota.
Rowan Tree Church
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Plants, 2021 The worldwide demand for avocados has resulted in the planting of millions of young plants each year. However, global warming, resulting in high temperatures, sensed as heat stress, may severely damage these new plantings. The objective of this study was
Or Shapira +4 more
doaj +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
The Rowan Tree Church 20th Annual Report, Hallows 2001 ce-Hallows 2002 ce. [PDF]
, 2000 This digital asset was created from the original digital scans by Rev. Paul V. Beyerl and provided to the Valdosta State University, Archives & Special Collections to be part of their Rowan Tree Church Periodicals Collection of the New Age Movements ...
Rowan Tree Church
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