Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan +11 more
wiley +1 more source
Erdos-Ko-Rado theorems for chordal graphs and trees
G. Hurlbert, Vikram Kamat
semanticscholar +1 more source
Surveillance of Migratory Shorebirds and Seabirds in 2024 in Australia Reveals Incursions of a Diversity of Low Pathogenicity Avian Influenza Viruses, but Not High Pathogenicity Avian Influenza H5N1. [PDF]
Wille M +21 more
europepmc +1 more source
This study systematically reveals a complex interactive network involving plants, microbes, and insects, elucidating the ecological and molecular mechanisms by which cotton enhances its resistance to aphids through the active recruitment of the beneficial soil bacterium Delftia tsuruhatensis.
Hui Xue +11 more
wiley +1 more source
Bipartite Embeddings of Trees in the Plane
M. Abellanas +4 more
semanticscholar +1 more source
Limited long-term changes in tree physiological function despite shifts in forest stand structure following moth (<i>Lymantria dispar</i> L.) outbreak and drought. [PDF]
Radwanski D +4 more
europepmc +1 more source
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang +12 more
wiley +1 more source
Assessing the inference of single-cell phylogenies and population dynamics from CRISPR lineage recordings. [PDF]
Pilarski J, Stadler T, Seidel S.
europepmc +1 more source
Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li +9 more
wiley +1 more source
Stem respiration increases in CO2‐enriched sweetgum trees
N. Edwards, T. Tschaplinski, R. Norby
semanticscholar +1 more source

