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Inhibitors for Novel Coronavirus Protease Identified by Virtual Screening of 687 Million Compounds

, 2020
The rapid outbreak of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China followed by its spread around the world poses a serious global concern for public health with almost 90000 people infected and thousands of fatalities ...
André Fischer   +4 more
semanticscholar   +1 more source

The potent small molecule integrin antagonist THR‐687 is a promising next‐generation therapy for retinal vascular disorders

Experimental Eye Research, 2019
Integrins are associated with various eye diseases such as diabetic retinopathy (DR) and wet age‐related macular degeneration (AMD) and implicated in main pathologic disease hallmarks like neovascularization, inflammation, fibrosis and vascular leakage ...
T. Hu   +8 more
semanticscholar   +1 more source

Pattern and Management of Recurrence of Mid‐Low Rectal Cancer After Neoadjuvant Intensity‐Modulated Radiotherapy: Single‐Center Results of 687 Cases

Clinical colorectal cancer, 2018
Background The purpose of this study was to retrospectively analyze the pattern and the management of recurrence of rectal cancer treated with 22‐fraction intensity‐modulated radiation therapy (IMRT). Patients and Methods This study included patients who
A. Wu   +6 more
semanticscholar   +1 more source

Identification of a novel HLA‐DPB1, HLA‐DPB1*687:01, in an Italian renal transplant candidate

HLA, 2019
Two adjacent nucleotide substitutions in exon 2 characterize the novel class II HLA‐DPB1*687:01 allele.
C. Biagini   +4 more
semanticscholar   +1 more source

Exploring the mediating roles of motivation and boredom in basic psychological needs and behavioural engagement in English learning: a self-determination theory perspective

BMC Psychology
In second language acquisition research, the psychological factors associated with language learning have been a prominent focus. The affective turn in and introduction of positive psychology in this field have further boosted research on the roles of ...
Honggang Liu, Ying Wang, Haoyue Wang
semanticscholar   +1 more source

National early warning score 2 plus non-invasive capnography and perfusion index to estimate poor outcomes in emergency departments.

American Journal of Emergency Medicine
BACKGROUND The study of the inclusion of new variables in already existing early warning scores is a growing field. The aim of this work was to determine how capnometry measurements, in the form of end-tidal CO2 (ETCO2) and the perfusion index (PI ...
R. López-Izquierdo   +9 more
semanticscholar   +1 more source

Cleft lip/palate and hereditary diffuse gastric cancer: report of a family harboring a CDH1 c.687 + 1G > A germline mutation and review of the literature

Familial Cancer, 2018
F. Obermair   +9 more
semanticscholar   +1 more source

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