Results 11 to 20 of about 20,451 (122)

General diseases and medications in 687 patients reporting on adverse effects from dental materials

Clinical Oral Investigations, 2023
Examination of patients claiming adverse effects from dental materials can be very challenging. Particularly, systemic aspects must be considered besides dental and orofacial diseases and allergies.
F. Cieplik, K. Hiller, K. J. Scholz, G. Schmalz, W. Buchalla, Pauline Mittermüller   +5 more
semanticscholar   +1 more source

Phase 1 Study of THR-687, a Novel, Highly Potent Integrin Antagonist for the Treatment of Diabetic Macular Edema

Ophthalmology Science, 2021
Purpose To evaluate the safety and preliminary efficacy of THR-687 in patients with center-involved diabetic macular edema (DME). Design Phase 1, open-label, multicenter, 3 + 3 dose-escalation study with 3-month follow-up.
A. Khanani, Sunil S. Patel, V. Gonzalez, S. J. Moon, G. Jaffe, J. Wells, P. Kozma, P. Dugel, R. Maturi   +8 more
semanticscholar   +1 more source

Remote liver injury following acute renal ischaemia–reperfusion: involvement of circulating exosomal miR‐687 and regulation by thymoquinone

Experimental Physiology, 2021
What is the central question of this study? What is the role of circulating exosomal miR‐687 in remote hepatic injury following renal ischaemia–reperfusion injury (IRI) and does thymoquinone have a modulatory impact?
H. Ashour, L. Rashed, M. Elkordy, O. Abdelwahed   +3 more
semanticscholar   +1 more source

Treatment with IMR-687, a Highly Selective PDE9 Inhibitor, Increases HbF and Reduces VOCs in Adults with Sickle Cell Disease in a Long-Term, Phase 2a, Open-Label Extension Study

Blood, 2021
Introduction IMR-687 (tovinontrine) is a highly selective phosphodiesterase 9 (PDE9) inhibitor being developed as an orally administered therapy for patients with sickle cell disease (SCD) and beta-thalassemia.
B. Andemariam, T. Mant, P. Eleftheriou, S. Lugthart, L. Bronte-Hall, F. Barroso, G. Blyden, James Mason, C. Barysauskas, J. Yen, Karen H. K. Tang, R. Ballal, K. Attie   +12 more
semanticscholar   +1 more source

Systemic exposure following intravitreal administration of therapeutic agents: an integrated pharmacokinetic approach. 2. THR-687

Journal of Pharmacokinetics and Pharmacodynamics, 2021
Intravitreal (IVT) injection remains the preferred administration route of pharmacological agents intended for the treatment of back of the eye diseases such as diabetic macular edema (DME) and neovascular age-related macular degeneration (nvAMD).
M. Vanhove, Jean-Marc Wagner, B. Noppen, B. Jonckx, Elke Vermassen, Alan W. Stitt   +5 more
semanticscholar   +1 more source

Rat Cytomegalovirus Virion-Associated Proteins R131 and R129 Are Necessary for Infection of Macrophages and Dendritic Cells

Pathogens, 2020
Cytomegalovirus (CMV) establishes persistent, latent infection in hosts, causing diseases in immunocompromised patients, transplant recipients, and neonates.
Iris K A Jones, Nicole N Haese, P. Gatault, Zachary J. Streblow, T. Andoh, Michael C. Denton, Cassilyn E Streblow, Kiley Bonin, C. Kreklywich, Jennifer M Burg, S. Orloff, D. Streblow   +11 more
semanticscholar   +1 more source

Long Noncoding RNA TCONS_00016406 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury by Regulating the miR-687/PTEN Pathway

Frontiers in Physiology, 2020
Acute kidney injury (AKI) is a common and serious complication of sepsis accompanied by kidney dysfunction resulting from various etiologies and pathophysiological processes.
Xuelan Liu, Na Zhu, Bo Zhang, S. Xu
semanticscholar   +1 more source

Evaluating the Moral Beliefs Encoded in LLMs [PDF]

Neural Information Processing Systems, 2023
This paper presents a case study on the design, administration, post-processing, and evaluation of surveys on large language models (LLMs). It comprises two components: (1) A statistical method for eliciting beliefs encoded in LLMs.
Nino Scherrer, Claudia Shi, Amir Feder, D. Blei   +3 more
semanticscholar   +1 more source

Israel y covid-19: ¿cómo se escribirá en el futuro la historia de la epidemia en este país? [PDF]

História, Ciências, Saúde: Manguinhos, 2022
Resumen El presente artículo representa un intento de reflexionar hipotéticamente sobre la manera en que los historiadores de la ciencia escribirán en el futuro sus investigaciones sobre el desarrollo de la pandemia de la covid-19 en Israel, dentro de un
Leo Corry
doaj   +1 more source

Benefits and Safety of Long-Term Use of IMR-687 As Monotherapy or in Combination with a Stable Dose of Hydroxyurea (HU) in 2 Adult Sickle Cell Patients

, 2020
Study Background IMR-687 is an inhibitor of phosphodiesterase 9 intended to treat sickle cell disease (SCD) by stimulating the production of fetal hemoglobin (HbF).
L. Bronte-Hall, B. Andemariam, Blyden Gershwin, S. Lugthart, T. Mant, J. Howard, H. Fok, P. Eleftheriou, R. Hagar, James Mason, R. Ballal, J. Lufkin, E. Lisbon   +12 more
semanticscholar   +1 more source