Results 21 to 30 of about 15,897,845 (139)
Expression of TNF-R1 in tracheal epithelium.
, 2014 A: In RT-PCR experiments using whole tracheal preparations we found evidence for mRNA of TNF-R1 but not TNF-R2 (n = 3, bp: 100 kD). B: In tracheae previously exposed to TNF-α over 60 min we observed a non-significant increase in TNF-R1 mRNA when using ...
Thomas Kohlen (535136) +6 more
core +1 more source
Discovery of Ligands for the TNFR1 Extracellular Domain Using Fragment‐Based Drug Discovery
ChemMedChem, Volume 21, Issue 13, 14 July 2026.The tumor necrosis factor receptor 1 (TNFR1) plays a major role in immunoregulation. We explored TNFR1 as a small‐molecule drug target using fragment‐based drug discovery. We found a picolinic acid fragment hit and characterized its binding mode in the extracellular domain of TNFR1.
Henri Chédotal +6 more
wiley +1 more source
Expression of TRAIL-R1-R4 and depletion of TRAIL-R1 in human cells.
, 2014 (A) A 2% agarose gel electrophoresis gel shows RT-PCR amplification of TRAIL-R1 (214 bp), TRAIL-R2 (145 bp), TRAIL-R3 (141 bp) and TRAIL-R4 (271 bp) mRNA from HeLa, THP-1 and HEK293 cell lines.
Servaas A. Morré (117588) +7 more
core +1 more source
Parameter Hierarchies and Language Contact: The Present Perfect in Ecuadorian Spanish1
Transactions of the Philological Society, Volume 124, Issue 2, Page 513-546, July 2026.Abstract This article explores the hypothesis that the ‘fine‐grained’ grammatical differences that adult grammars under contact are said to be sensitive to (e.g., Hicks et al. 2023) amount to micro/nanoparametric distinctions, in the sense of Roberts (2019).
Norma Schifano
wiley +1 more source
Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.Seventeen new quinazolinone derivatives were synthesized in pure form. Compound 4j showed the highest inhibitory activity against the A549 cell line and induced apoptosis via caspase‐3 activation in MCF‐7 cells. 4j inhibited EGFR enzyme twice as effectively as gefitinib.
Aybüke Züleyha Kaya +3 more
wiley +1 more source
Relaxivity constants r1 or r2 of SPIO nanoparticles added to RBCs.
, 2013 r1 (A) and r2 (B) relaxivity constants of SPIO nanoparticles added to human RBCs. r1 (C) and r2 (D) relaxivity constants of SPIO nanoparticles added to murine RBCs.
Carla Sfara (477067) +8 more
core +1 more source
Ecological Entomology, Volume 51, Issue 3, Page 475-488, June 2026.Using multiple infected and uninfected Drosophila sturtevanti lines, we investigated (i) the impact of Wolbachia on fecundity and (ii) its effects relative to antibiotic treatment. Based on over 1680 dissected ovaries, fecundity was similar between infected and uninfected flies.
Letícia Carlesso de Paula Sena +4 more
wiley +1 more source
Relays and communities mediating R1-R1 signal processing.
, 2019 A. Community membership and top couplings (yellow lines) of the native dimer. B. Eigen-centrality map of the native dimer. C. Community membership and top couplings (orange lines) of the phosphorylated (TPO) dimer. D.
Howard Schulman (239804) +2 more
core +1 more source
Electro‐Chemo‐Mechanical Coupling in Hf0.5Zr0.5O2 Ferroionic Heterostructures
Advanced Functional Materials, Volume 36, Issue 37, 7 May 2026.Schematic of a ferroionic HZO heterostructure where epitaxial interfaces enable dynamic oxygen‐vacancy exchange, coupling ionic and ferroelectric degrees of freedom. Vacancy‐mediated polarization modulation biases HZO polymorphism, suppresses leakage, and enhances piezoelectric response, yielding distinct butterfly‐loop evolution and diode‐like ...
Achilles Bergne +17 more
wiley +1 more source
Transfection with GABABR1 siRNA in 3T3-L1 cells.
, 2013 (A) 3T3-L1 cells transfected with si-control and si-GABABR1 were cultured for 3 days, followed by immunoblotting for GABABR1 subunit. (B) 3T3-L1 cells transfected with siRNA were cultured for 2 days in the presence of inducers of adipocytic ...
Yoshifumi Takahata (350536) +8 more
core +1 more source