Results 21 to 30 of about 15,061,658 (124)

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

open access: yesAdvanced Science, Volume 13, Issue 11, 23 February 2026.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva   +28 more
wiley   +1 more source

Comparison of ultrasound with computed tomography and whole‐body diffusion‐weighted MRI in prediction of surgical outcome using ESMO‐ESGO criteria in patients with tubo‐ovarian carcinoma: prospective ISAAC study

open access: yesUltrasound in Obstetrics &Gynecology, Volume 67, Issue 2, Page 207-219, February 2026.
ABSTRACT Objective To test the non‐inferiority of extended abdominopelvic ultrasound examination compared with contrast‐enhanced computed tomography (CT) and whole‐body diffusion‐weighted magnetic resonance imaging (WB‐DWI/MRI) in discriminating preoperatively between resectable and non‐resectable disease based on the European Society for Medical ...
D. Fischerova   +26 more
wiley   +1 more source

Selection maintains floral color polymorphism in scarlet paintbrush, Castilleja coccinea, reflecting combined ecological factors

open access: yesAmerican Journal of Botany, Volume 113, Issue 1, January 2026.
Abstract Premise Evolutionary theory predicts polymorphism should be rare; however, intraspecific variation in floral color is common and can be attributed to genetic drift, plasticity, or variable selection. Examining floral color polymorphism both within contact zones and across a species' range can reveal the mechanisms maintaining this variation ...
Emma Fetterly   +6 more
wiley   +1 more source

Mapping the density of giant trees in the Amazon

open access: yesNew Phytologist, Volume 249, Issue 1, Page 152-168, January 2026.
Summary Tall trees (height ≥ 60 m) are keystone elements of tropical forests, strongly influencing biodiversity, carbon storage, and ecosystem resilience. Yet, their density and spatial distribution remain poorly quantified, especially in remote Amazonian regions, limiting our understanding of their ecological roles and contribution to forest–climate ...
Robson Borges de Lima   +20 more
wiley   +1 more source

The Mycovirus Cryphonectria Hypovirus 1 Infects the Heterologous Host Fusarium oxysporum and Induces Hypovirulence

open access: yesPlant Pathology, Volume 75, Issue 1, January/February 2026.
The Cryphonectria parasitica hypovirus CHV1 efficiently replicates in the heterologous host Fusarium oxysporum, inducing clear hypovirulence, and has the potential to persist and spread in this pathogen by constant infections and re‐infections through hyphal anastomosis.
María Carmen Cañizares   +2 more
wiley   +1 more source

Image1_TRAIL-R1-Targeted CAR-T Cells Exhibit Dual Antitumor Efficacy.jpg

open access: yes, 2021
Tumor necrosis factor–related apoptosis-inducing ligand receptor 1 (TRAIL-R1) has limited expression in normal tissues but was highly expressed in various types of tumors, making it an attractive target for cancer immunotherapy.
Wang Wang (262236)   +9 more
core   +1 more source

Downconversion Master Slave OCT With a Bidirectional Sweeping Laser

open access: yesJournal of Biophotonics, Volume 18, Issue 12, December 2025.
ABSTRACT This paper explores the challenges of signal processing when using optical coherence tomography (OCT) imaging instruments driven by asymmetric MHz bidirectional sweeping lasers. A downconversion master–slave (DMS) method is proposed as a viable alternative to the traditional OCT protocol.
A. Martinez Jimenez   +8 more
wiley   +1 more source

Image3_TRAIL-R1-Targeted CAR-T Cells Exhibit Dual Antitumor Efficacy.jpg

open access: yes, 2021
Tumor necrosis factor–related apoptosis-inducing ligand receptor 1 (TRAIL-R1) has limited expression in normal tissues but was highly expressed in various types of tumors, making it an attractive target for cancer immunotherapy.
Wang Wang (262236)   +9 more
core   +1 more source

Serial Chemical Crystallography for Autonomous Quantitative Phase Analysis in an Electron Microscope

open access: yesSmall Methods, Volume 9, Issue 12, December 1, 2025.
t‐SerialED, a novel electron diffraction method, enables rapid, high‐throughput structural analysis of nano‐sized materials. By adapting a batch‐by‐batch data collection approach, t‐SerialED integrates 3D reciprocal information to serial crystallography datasets.
Taimin Yang   +5 more
wiley   +1 more source

Physiological roles of lignins – tuning cell wall hygroscopy and biomechanics

open access: yesNew Phytologist, Volume 248, Issue 6, Page 2674-2706, December 2025.
Summary Lignins constitute the second most abundant carbon‐storing biopolymers in the biosphere. These phenolic polymers accumulate in different concentrations, compositions, and localisations within and between cell wall layers and cell types. Lignins were acquired during plant terrestrialisation 450 million years ago, and the diversification of their
Edouard Pesquet   +3 more
wiley   +1 more source

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