Results 21 to 30 of about 452,049 (113)

Effects of isocaloric high-fat diet on energy metabolism and endurance exercise capacity in SD rats

open access: yes陆军军医大学学报
Objective To investigate the effects of a 45% high-fat diet (HFD) with isocaloric intake on energy metabolism and endurance exercise capacity in SD rats. Methods Twenty-four male SD rats were randomly divided into normal chow diet group (CON), HFD group,
CHEN Shuai, DENG Xiangyuan, LANG Hedong
doaj   +1 more source

Improved Heat Transfer Capabilities of Nanofluids—An Assessment Through CFD Analysis

open access: yesChemical Engineering &Technology, Volume 47, Issue 11, November 2024.
Conventional fluids used in fission‐based water‐cooled nuclear reactors have lower heat transfer coefficients and thermal conductivity, prompting researchers to explore high‐performance fluids to enhance heat transfer and prevent core meltdown during accidents. It is crucial to investigate fluids that can improve thermal hydraulic characteristics, such
Rehan Zubair Khalid   +4 more
wiley   +1 more source

Effect and underlying mechanism of glutamine on radiosensitivity of colon cancer cells

open access: yes陆军军医大学学报
Objective To observe the effect of different concentrations of glutamine (Gln) on the radiosensitivity of colorectal cancer HT-29 cells and explore the possible mechanism.
LU Heng, NI Xiangmin, YU Shengcai
doaj   +1 more source

Elucidation of the mechanism of Gualou-Xiebai-Banxia decoction for the treatment of unstable angina based on network pharmacology and molecular docking

open access: yesWorld Journal of Traditional Chinese Medicine, 2023
Objective: The aim of this study was to identify the potential pharmacological mechanisms of Gualou-Xiebai-Banxia decoction (GLXBBX) against unstable angina (UA).
Yu Tan   +4 more
doaj   +1 more source

Del-1 nanoparticles/silk fibroin hydrogel accelerates the healing of chronic skin wounds by promoting inflammation regression

open access: yes陆军军医大学学报
Objective To investigate the effect of silk fibroin hydrogel loaded with developmental endothelial locus-1 (Del-1) nanoparticles on the healing of chronic skin wounds in mice.
KAN Xuewei, YAO Pingping, CHEN Jiaqi
doaj   +1 more source

Time to Functional Loss as an Endpoint in Huntington's Disease Trials: Enrichment and Sample Size

open access: yesMovement Disorders, Volume 39, Issue 10, Page 1809-1816, October 2024.
Abstract Background Clinical trial scenarios can be modeled using data from observational studies, providing critical information for design of real‐world trials. The Huntington's Disease Integrated Staging System (HD‐ISS) characterizes disease progression over an individual's lifespan and allows for flexibility in the design of trials with the goal of
James A. Mills   +6 more
wiley   +1 more source

Multiple treatment interruptions and protecting HIV-specific CD4 T cells enable durable CD8 T cell response and viral control

open access: yesFrontiers in Medicine
Human Immunodeficiency Virus (HIV) remains a global health challenge, and novel approaches to improve HIV control are significantly important. The cell and gene therapy product AGT103-T was previously evaluated (NCT04561258) for safety, immunogenicity ...
Anshika Jain   +13 more
doaj   +1 more source

SMALL BOWEL CONTUSION AND PERFORATION DUE TO UNCOMMON BLUNT ABDOMINAL TRAUMA

open access: yesSanamed, 2023
Introduction: Small bowel injuries are rare, accounting for only 1% – 5% of injuries following blunt abdominal trauma, while small bowel perforation has been reported in 0.3% of patients. Delays in early diagnosis or misdiagnosis significantly contribute
Niksic Hana   +7 more
doaj   +1 more source

VITAMIN D LEVELS AND VDR rs2228570 GENETIC VARIANT IN AUTOIMMUNE THYROIDITIS

open access: yesSanamed, 2023
Autoimmune Thyroiditis (AIT) is a prevalent autoimmune disorder characterized by an immune response targeting the thyroid gland. Genetic factors play a significant role in AIT susceptibility, with immune-related genes, especially the vitamin D receptor ...
Shaikh Parveen Aleena   +2 more
doaj   +1 more source

Formulation of hesperidin‐loaded in situ gel for ocular drug delivery: a comprehensive study

open access: yesJournal of the Science of Food and Agriculture, Volume 104, Issue 10, Page 5846-5859, 15 August 2024.
Abstract BACKGROUND Allergic conjunctivitis is one of the most common eye disorders. Different drugs are used for its treatment. Hesperidin is an active substance isolated from Citrus sinensis L. (Rutaceae) fruit peels, with known anti‐inflammatory activity but low solubility.
Sefa Gözcü   +11 more
wiley   +1 more source

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