Results 1 to 10 of about 3,332,671 (263)

R&D Costs of New Medicines: A Landscape Analysis [PDF]

Frontiers in Medicine, 2021
Over the years, questions have been raised over R&D costs of new medicines. The aim of this study is to conduct a landscape review of the (drivers of) R&D costs of a new medicine derived from the peer-reviewed and grey literature.
Steven Simoens, Isabelle Huys
doaj   +3 more sources

“ACEing” the Evidence Within Physical Medicine and Rehabilitation (PM&R) [PDF]

MedEdPORTAL, 2020
Introduction While evidence-based medicine (EBM) is important in all fields of medicine, it can be specifically challenging for the field of physical medicine and rehabilitation (PM&R), a rapidly developing field where the standard hierarchy of evidence ...
Sarah H. Yoon, Mary Kim, Christopher Tarver, Lawrence K. Loo   +3 more
doaj   +3 more sources

Lewis Paul D: R for Medicine and Biology

Journal of Pathology Informatics, 2010
G William Moore
doaj   +2 more sources

R-group Replacement Database for Medicinal Chemistry

Future Science OA, 2021
Generation of an R-group replacement system for compound optimization in medicinal chemistry.From bioactive compounds, analogue series (ASs) were systematically extracted and from these ASs, all R-groups were isolated and further analyzed.From more than 17,000 ASs, more than 50,000 unique R-groups were isolated.
Kosuke Takeuchi, Ryo Kunimoto, Jürgen Bajorath   +2 more
openaire   +3 more sources

Multiobjective Differential Evolution Clustering Algorithm Based on Multimedia Information in Working Mechanism Innovation for Traditional Chinese Medicine

Advances in Multimedia, 2022
Aiming at working mechanism innovation for traditional Chinese medicine, a multiobjective differential evolution clustering algorithm based on multimedia information is proposed and applied.
Xiaoling Zhu, Hongsheng Cheng, Xu Zhang, Huaxu Zhu, Zhiguang Sun   +4 more
doaj   +1 more source

The addition of FAIMS increases targeted proteomics sensitivity from FFPE tumor biopsies

Scientific Reports, 2022
Mass spectrometry-based targeted proteomics allows objective protein quantitation of clinical biomarkers from a single section of formalin-fixed, paraffin-embedded (FFPE) tumor tissue biopsies.
Steve Sweet, David Chain, Wen Yu, Philip Martin, Marlon Rebelatto, Andrew Chambers, Fabiola Cecchi, Yeoun Jin Kim   +7 more
doaj   +1 more source

Estimation of multivariate detection limits of four quality parameters in licorice using MEMS–NIR spectrometry coupled with two sampling accessories [PDF]

Journal of Innovative Optical Health Sciences, 2015
In this work, multivariate detection limits (MDL) estimator was obtained based on the micro-electro-mechanical systems–near infrared (MEMS–NIR) technology coupled with two sampling accessories to assess the detection capability of four quality parameters
Zhisheng Wu, Xinyuan Shi, Na Zhao, Yanling Pei, Manfei Xu, Luwei Zhou, Yang Li, Yanjiang Qiao   +7 more
doaj   +1 more source

Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers

Nature Communications, 2021
A recent clinical trial shows that a proportion of lung cancer patients carrying the EGFR T790M mutation develop resistance to osimertinib. In this study, the authors show that T790M subclonality is associated with worse clinical outcome likely through ...
Tereza Vaclova, Ursula Grazini, Lewis Ward, Daniel O’Neill, Aleksandra Markovets, Xiangning Huang, Juliann Chmielecki, Ryan Hartmaier, Kenneth S. Thress, Paul D. Smith, J. Carl Barrett, Julian Downward, Elza C. de Bruin   +12 more
doaj   +1 more source

Near-infrared chemical imaging for quantitative analysis of chlorpheniramine maleate and distribution homogeneity assessment in pharmaceutical formulations [PDF]

Journal of Innovative Optical Health Sciences, 2016
Near infrared chemical imaging (NIR-CI) combines conventional near infrared (NIR) spectroscopy with chemical imaging, thus provides spectral and spatial information simultaneously.
Manfei Xu, Luwei Zhou, Qiao Zhang, Zhisheng Wu, Xinyuan Shi, Yanjiang Qiao   +5 more
doaj   +1 more source

Drug research and development opportunities in low- and middle-income countries: accelerating traditional medicine through systematic utilization and comprehensive synergy

Infectious Diseases of Poverty, 2022
Background Though the utilization of traditional medicine has been proposed for modern drug research and development (R&D), limited research has discussed its feasible paths.
Guangqi Liu, Yan Xie, Yinuo Sun, Kaixuan Zhang, Jiyan Ma, Yangmu Huang   +5 more
doaj   +1 more source