Results 121 to 130 of about 3,332,671 (263)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida +10 morewiley +1 more sourceRecurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa +15 morewiley +1 more sourceFamily History and Solar Insolation in Bipolar I Disorder. [PDF]
Acta Psychiatr ScandBauer M, Glenn T, Achtyes ED, Alda M, Agaoglu E, Altınbaş K, Andreassen OA, Angelopoulos E, Ardau R, Aydin M, Ayhan Y, Baethge C, Bauer R, Baune BT, Balaban C, Becerra-Palars C, Behere AP, Belete H, Belete T, Belizario GO, Bellivier F, Belmaker RH, Benedetti F, Berk M, Bersudsky Y, Bicakci Ş, Birabwa-Oketcho H, Bjella TD, Brady C, Cabrera J, Cappucciati M, Castro AMP, Chen W, Cheung EYW, Chiesa S, Chanopoulou M, Crowe M, Cuomo A, Dallaspezia S, Desai P, Dodd S, Etain B, Fagiolini A, Fellendorf FT, Ferensztajn-Rochowiak E, Fiedorowicz JG, Fountoulakis KN, Frye MA, Geoffroy PA, Gitlin MJ, Gonzalez-Pinto A, Gottlieb JF, Grof P, Haarman BCM, Harima H, Hasse-Sousa M, Henry C, Hoffding L, Houenou J, Imbesi M, Isometsä ET, Ivkovic M, Janno S, Johnsen S, Kapczinski F, Karakatsoulis GN, Kardell M, Kessing LV, Kim SJ, König B, Kot TL, Koval M, Kunz M, Lafer B, Landén M, Larsen ER, Licht RW, Ludwig VM, Lopez-Jaramillo C, MacKenzie A, Madsen HØ, Madsen SAKA, Mahadevan J, Mahardika A, Mahfoudh K, Manchia M, Marsh W, Martinez-Cengotitabengoa M, Martini J, Martiny K, Mashima Y, McLoughlin DM, Meesters ANR, Meesters Y, Melle I, Meza-Urzúa F, Michaelis E, Mikolas P, Mok YM, Monteith S, Moorthy M, Morken G, Mosca E, Mozzhegorov AA, Munoz R, Mythri SV, Nadella RK, Nakanotani T, Nielsen RE, O'Donovan C, Omrani A, Osher Y, Ouali U, Pantovic-Stefanovic M, Pariwatcharakul P, Petite J, Pfennig A, Pilhatsch M, Ruiz YP, Pinna M, Pompili M, Porter R, Quiroz D, Rabelo-da-Ponte FD, Ramesar R, Rasgon N, Ratta-Apha W, Redahan M, Reddy MS, Reif A, Reininghaus EZ, Richards JG, Ritter P, Rybakowski JK, Sathyaputri L, Scippa AM, Simhandl C, Smith D, Smith J, Stackhouse PW, Stein DJ, Stilwell K, Strejilevich S, Su KP, Subramaniam M, Sulaiman AH, Suominen K, Tanra AJ, Tatebayashi Y, Teh WL, Tondo L, Torrent C, Tuinstra D, Uchida T, Vaaler AE, Vieta E, Viswanath B, Volf C, Yang KJ, Yoldi-Negrete M, Yalcinkaya OK, Young AH, Zgueb Y, Whybrow PC. +163 moreeuropepmc +1 more sourcePeroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski +17 morewiley +1 more sourceCrucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel +10 morewiley +1 more sourceCorrection: Quality of life improvements associated with weight loss using a novel shape-shifting hydrogel capsule: RESET study results. [PDF]
Int J Obes (Lond)Kushner RF, Ard JD, Wadden TA, O'Neil PM, Bays HE, Greenway FL, Jakicic JM, Wyatt HR, Kenan Y, Asaraf LC, Donna H Ryan. +10 moreeuropepmc +1 more sourcePhenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer +9 morewiley +1 more sourceSocial Determinants of Health and Pediatric Long COVID in the US. [PDF]
JAMA PediatrRhee KE, Thaweethai T, Pant DB, Stein CR, Salisbury AL, Kinser PA, Kleinman LC, Gallagher R, Warburton D, Mohandas S, Snowden JN, Stockwell MS, Tantisira KG, Flaherman VJ, Teufel RJ, Castro L, Chung A, Espinoza Esparza J, Hockett CW, Isidoro-Chino M, Krishnan A, McCormack LA, Nabower AM, Nahin ER, Rosas JM, Siddiqui S, Szmuszkovicz JR, Vangeepuram N, Zimmerman E, Brown HE, Carmilani M, Coombs K, Fisher L, Witvliet MG, Wood JC, Milner JD, Rosenzweig EB, Irby K, Karlson EW, Qian Z, Lamendola-Essel MF, Hasson DC, Katz SD, Yin HS, Foulkes AS, Gross RS, RECOVER-Pediatrics Group; and the ABCD-RECOVER Group; for the RECOVER-Pediatrics Consortium
, Aschner JL, Atz AM, Banerjee D, Bogie A, Bukulmez H, Clouser K, Cottrell LA, Cowan K, D'Sa VA, Dozor AJ, Elliott AJ, Faustino EVS, Fiks AG, Gaur S, Gennaro ML, Gordon ST, Hasan UN, Hester CM, Hogan AH, Hsia DS, Kaelber DC, Kosut JS, Krishnan S, McCulloh RJ, Michelow IC, Nolan SM, Oliveira CR, Pace WD, Palumbo P, Raissy H, Reyes A, Ross JL, Salazar JC, Selvarangan R, Stevenson MD, Werzberger A, Westfall JM, Zani K, Zempsky WT, Chan J, Metz TD, Newburger JW, Truong DT, Feldman CH, Aupperle R, Baker FC, Banich MT, Barch DM, Baskin-Sommers A, Bjork JM, Dapretto M, Brown SA, Casey BJ, Chang L, Clark DB, Dale AM, Ernst TM, Fair DA, Feldstein Ewing SW, Foxe JJ, Freedman EG, Friedman NP, Garavan H, Gee DG, Gonzalez R, Gray KM, Heitzeg MM, Herting MM, Jacobus J, Laird AR, Larson CL, Lisdahl KM, Luciana M, Luna B, Madden PAF, McGlade EC, Müller-Oehring EM, Nagel BJ, Neale MC, Paulus MP, Potter AS, Renshaw PF, Sowell ER, Squeglia LM, Uddin LQ, Wilson S, Yurgelun-Todd DA. +133 moreeuropepmc +1 more source
