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Development and validation of a clinical scoring system for the prediction of methotrexate treatment response in rheumatoid arthritis patients: a multicenter real-world study. [PDF]

Ther Adv Musculoskelet Dis
Hidayat R, Fauzia F, Kusumo Wibowo SA, Ariane A, Partan RU, Muthia P, Warlisti IV, Suntoko B, Pratama MZ, Wahono CS, Rahmawati LD, Kurniari PK, Utomo AK, Najirman N, Kurniawan E, Werdiningsih Y, Pango F, Dhifanra MA, Audrey J, Parlindungan F.   +19 more
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Accuracy and Reliability of AI Models in Emergency Myocardial Infarction Education. [PDF]

Emerg Med Int
Korkmaz İ.
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Introducing the Dutch Quality Registry for Acute Internal Medicine (DRAIM): Method of development and opportunities of use from a single-centre pilot study. [PDF]

PLoS One
van der Velde MGAM, Mols EM, Alsma J, Nanayakkara PWB, Haak HR, Kremers MNT, research consortium acute medicine ORCA.   +6 more
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Dengue severity and profiles of complement activation and immune mediators: A multicenter cohort study in Indonesia. [PDF]

PLoS One
Saptarini I, Masyeni S, Harahap AR, Giantini A, Nugroho P, Handito A, Hendarwan H, Susilo A, Haryanto S, Fitriani D, Sasmono RT, Nelwan EJ.   +11 more
europepmc   +1 more source

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Systematic mapping of R-group space enables the generation of an R-group replacement system for medicinal chemistry

European Journal of Medicinal Chemistry, 2021
Selection of R-groups (substituents, functional groups) is of critical importance for the generation of analogues during hit-to-lead and lead optimization. In the practice of medicinal chemistry, R-group selection is mostly driven by chemical experience and intuition taking synthetic criteria into account.
Kosuke Takeuchi, Ryo Kunimoto, Jürgen Bajorath   +2 more
openaire   +2 more sources