Results 281 to 290 of about 5,246,646 (349)

Systematic mapping of R-group space enables the generation of an R-group replacement system for medicinal chemistry

European Journal of Medicinal Chemistry, 2021
Selection of R-groups (substituents, functional groups) is of critical importance for the generation of analogues during hit-to-lead and lead optimization. In the practice of medicinal chemistry, R-group selection is mostly driven by chemical experience and intuition taking synthetic criteria into account.
Kosuke Takeuchi, Ryo Kunimoto, Jürgen Bajorath   +2 more
openaire   +2 more sources

Analysis of reimbursement (R) for next generation sequencing (NGS) on patients' tumors in the context of a personalized medicine program.

Journal of Clinical Oncology, 2017
6506 Background: R policies for NGS testing vary widely among private and public insurers. While drug costs are the greatest challenge in personalized or precision medicine, cost and R are substantial barriers to genomic profiling with NGS. We examined variation in coverage and R for a cohort of cancer patients (pts) treated at a tertiary oncology ...
Thomas D. Brown, Mariko Tameishi, Xiaoyu Liu, James Scanlan, J. David Beatty, Charles Drescher, John M. Pagel, Philip Jordan Gold, Shlece Alexander, Lauren K. Summers, Madeleine Brindle, Nina Varghis, James Yates, Kathleen N. Fondren, George Richard Birchfield, David Edwin Dong, Tara L. Benkers, Tanya A. Wahl, Scott David Ramsey, Anna Belinda Berry   +19 more
openaire   +1 more source

Commentary on R&D Trends Away from General Medicine/Cardiovascular Drugs: Can the FDA Help Reverse the Trend?

Clinical Pharmacology & Therapeutics, 2017
In the latter part of the 20th century, drug development in cardiovascular diseases (CVDs) was a paragon of “modern” therapeutics, bringing about a substantial number of effective, well‐tolerated agents targeting some of the most prevalent diseases of the Western world.
openaire   +2 more sources

General Medicinal Properties and Biocompatibility of Hemidesmus indicus R. Br. Aqueous Plant Extract

2023
Hewa Dikkumburage Tharindu Madhuranga, W A S H Dharmasena, T G K U Thambiliyagoda, G K B C M Gunasena, M C M Riham, Nirmani Ann Samarakoon, H.M.L.P.B. Herath   +6 more
openaire   +1 more source

Y.Ni, S. Sun, I. Oparaocha, L. Humeau, B. Davis, R. Cohen, G. Binder, Y.‐N. Chan, V. Slepushkin, and B. Dropulic, ‘Generation of a packaging cell line for prolonged large‐scale production of high‐titer HIV‐1‐based lentiviral vector’ Journal of Gene Medicine, 2005; Vol. 7, No. 6, 818–834

The Journal of Gene Medicine, 2005
AbstractThe original article to which this Erratum refers was published in The Journal of Gene Medicine, 7 (6) 2005, 818–834.
openaire   +1 more source

Radiotheranostics in oncology: Making precision medicine possible

Ca-A Cancer Journal for Clinicians, 2023
Eric Aboagye
exaly  

EXPLORATORY LAPAROTOMY IN THE SEPTIC PATIENT WITH ORGAN FAILURE F. SUTHERLAND (R-IV). DIVISION OF GENERAL, SURGERY. DEPARMENT OF SURGERY. FACULTY OF MEDICINE. UNIVERSITY OF CALCARY. CALCARY. ALBERTA

The Journal of Trauma: Injury, Infection, and Critical Care, 1987
W. E. DUNLOP, CALCARY ALBERTA
openaire   +1 more source