Results 111 to 120 of about 10,014,798 (291)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
An R Package for Dynamic Linear Models
Journal of Statistical Software, 2010 We describe an R package focused on Bayesian analysis of dynamic linear models. The main features of the package are its flexibility to deal with a variety of constant or time-varying, univariate or multivariate models, and the numerically stable ...
Giovanni Petris
doaj
On 2D and 3D parameter derivatio n for r ainfall- r unoff models [PDF]
Acta Montanistica Slovaca, 2012 Geoinformation technology, particularly GIS and digital terrain models, is commonly used at present in order to derive parameters of basins and flow paths. These parameters are subsequently used to create spatially based rainfall-runoff models.
Martin Adamec +4 more
doaj
Segmentation as Retention and Recognition: the R&R model
, 2017 We present the Retention and Recognition model (R&R), a probabilistic exemplar model that accounts for segmentation in Artificial Language Learning experiments. We show that R&R provides an excellent fit to human responses in three segmentation experiments with adults (Frank et al., 2010), outperforming existing models. Additionally, we analyze
Alhama, Raquel G., Zuidema, Willem
openaire +3 more sources
, 2014 <em> Editor’s note: This is the first in a series of posts from rOpenSci’s recent hackathon. </em> I recently had the pleasure of participating in rOpenSci’s hackathon. To be honest, I was quite nervous to work among such notables, but I immediately felt welcome thanks to a warm and personable group.
openaire +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Integrated Degradation Models in R Using iDEMO
Journal of Statistical Software, 2012 Degradation models are widely used to assess the lifetime information for highly reliable products with quality characteristics whose degradation over time can be related to reliability.
Chien-Yu Peng, Ya-Shan Cheng
doaj