Results 121 to 130 of about 1,111,830 (263)

Fechnerian Scaling in R: The Package fechner

Journal of Statistical Software, 2009
Fechnerian scaling is a procedure for constructing a metric on a set of objects (e.g., colors, symbols, X-ray films, or even statistical models) to represent dissimilarities among the objects "from the point of view" of a system (e.g., person, technical ...
Ehtibar N. Dzhafarov, Thomas Kiefer, Ali Ünlü   +2 more
doaj  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

malariasimple: An R package for fast simulations of malaria transmission. [PDF]

PLoS Comput Biol
Shackleton D, Ferguson N, Okell L, Churcher T, Winskill P.   +4 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

A Fast, Flexible Simulation Framework for Bayesian Adaptive Designs-The R Package BATSS. [PDF]

Pharm Stat
Couturier DL, Puhr R, Heritier S, Jaki T, Ryan EG.   +4 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

MeTime: an R package for reproducible longitudinal metabolomics data analysis. [PDF]

Bioinform Adv
Marella B, Weinisch P, Vehovec L, Tran V, Bless JJ, Njipouombe Nsangou YA, Kastenmüller G, Arnold M.   +7 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Metabodeconplus-An R Package for Automated Deconvolution and Alignment of 1D NMR Metabolomics Data. [PDF]

Metabolites
Schmidt T, Sombke M, Zacharias HU, Oefner PJ, Spang R, Gronwald W, GCKD Investigators.   +6 more
europepmc   +1 more source