Results 71 to 80 of about 8,158,678 (300)

ARDL modeling using R software

, 2023
Abstract The goal of this paper is helping to apply ARDL models using the R software. We will cover its benefits, show how to use the packages and will make interesting recommendations for estimating models ARDL using R.
openaire   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Study on the Convergence Behavior of Expectation Maximization Algorithm for Laplace Mixture Model [PDF]

Revista Română de Statistică, 2019
Laplace mixture model is widely used in lifetime applications. The estimation of model parameters is required to analyze the data. In this paper, the expectation maximization algorithm is used to obtain the estimates of parameters.
Zakiah Ibrahim KALANTAN, Faten ALREWELY, Kamarul Ariffin MANSOR   +2 more
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

A Search-Based Domain Adaptation Network for Fault Diagnosis of Rotating Machinery Under Cross-Operating Conditions

IEEE Access
Most domain adaptation diagnostic methods focus only on minimizing the distribution discrepancy between domains but fail to learn discriminative features among different classes of data.
Jiaqi Zhang, Hua Sun, Tong Yuan
doaj   +1 more source

Coexistence of Ferroelectricity and Ferromagnetism in Fullerene‐Based One‐Dimensional Chains

Advanced Science, 2023
One‐dimensional (1D) magnetoelectric multiferroics are promising multifunctional materials for miniaturized sensors, actuators, and memories. However, 1D materials with both ferroelectricity and ferromagnetism are quite rare.
Yang Zhao, Yu Guo, Yan Qi, Xue Jiang, Yan Su, Jijun Zhao   +5 more
doaj   +1 more source

Challenges of open innovation: the paradox of firm investment in open-source software [PDF]

, 2006
Open innovation is a powerful framework encompassing the generation, capture, and employment of intellectual property at the firm level. We identify three fundamental challenges for firms in applying the concept of open innovation: finding creative ways ...
Brandenburger A.M., Campbell-Kelly M., Chandler A.D., Chesbrough H.W., Chesbrough H.W., Conant J., Freedman D.H., Glaser B., Hars A., Jaffe A.B., Kaplan J., Katz M.L., Lawler E.E., Lerner J., McKusick K., Moore G.A., Ouchi W.G., Perens B., Shapiro C., Smith D.K., Tennenhouse D., Valimaki M., von Hippel E., West J.   +23 more
core   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

ECRNet: Hybrid Network for Skin Cancer Identification

IEEE Access
Skin cancer recognition poses a significant challenge in the field of deep learning. While conventional convolutional neural networks have been extensively employed for classifying skin cancer images, their fixed receptive field limits their ability to ...
Wu Di, Fan Xin, Long Yu, Zhao Hui, He Ping, Su Hui   +5 more
doaj   +1 more source