Results 71 to 80 of about 8,226,807 (254)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
R behind the scenes: Using S the (un)usual way [PDF]
, 2007 R is not only a program for analyzing and visualizing data, it is an open and programmable software environment. It can not only easily access other programs written in a wide variety of languages, but also be accessed itself from other programs. As such,
Leisch, Friedrich
core +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
ECRNet: Hybrid Network for Skin Cancer Identification
IEEE AccessSkin cancer recognition poses a significant challenge in the field of deep learning. While conventional convolutional neural networks have been extensively employed for classifying skin cancer images, their fixed receptive field limits their ability to ...
Wu Di +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Journal of Mazandaran University of Medical Sciences, 2022 Background and purpose: Asthma is a chronic inflammatory disorder of the airways caused by a combination of complex environmental and genetic interactions.
Saeed Pirmoradi
doaj
Development of an application for accessing and analyzing RDPLF data
Bulletin de la Dialyse à Domicile, 2020 The collection of information in the database of a medical registry finds its first interest in the possibility for a doctor and a care team to analyze their results and to compare themselves with other teams for the purpose of sharing experience and ...
Benoit Thieurmel, Martin Masson
doaj +1 more source
Integrating R and Hadoop for Big Data Analysis [PDF]
, 2014 Analyzing and working with big data could be very diffi cult using classical means like relational database management systems or desktop software packages for statistics and visualization.
Dragoescu, Raluca Mariana +1 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source