Results 1 to 10 of about 20,570 (99)

Chromatographic analysis of selected phytosterols from Cyathea and their characterization by in silico docking to potential therapeutic targets

open access: yesCurrent Research in Toxicology, 2023
Separation and quantification of lupeol, stigmasterol and swertiamarin in ethanolic extracts of selected Cyathea species have been developed using HPTLC and an attempt is made to explore the biopotential of phytochemicals against various proteins by ...
N. Janakiraman   +6 more
doaj   +1 more source

The effects of simvastatin and fenofibrate on malondialdehyde and reduced glutathione concentrations in the plasma, liver, and brain of normolipidaemic and hyperlipidaemic rats

open access: yesArhiv za Higijenu Rada i Toksikologiju, 2023
The objective of study was to investigate the effects of different doses of simvastatin and fenofibrate on malondialdehyde (MDA) and reduced glutathione (GSH) in the plasma, liver, and brain tissue of male normolipidaemic and hyperlipidaemic rats ...
Vukšić Antonija   +7 more
doaj   +1 more source

Enhancing developmental and reproductive toxicity knowledge: A new AOP stemming from glutathione depletion

open access: yesCurrent Research in Toxicology, 2023
Integrated approaches to testing and assessments (IATAs) have been proposed as a method to organise new approach methodologies in order to replace traditional animal testing for chemical safety assessments.
Alun Myden   +5 more
doaj   +1 more source

Chemistry Academic Program Review [PDF]

open access: yes, 2023
This report summarizes an evaluation of the UNT Libraries' Chemistry-related resources and materials to determine if the collection is adequately serving patron needs.
Harker, Karen
core  

New in vitro findings about halogenated boroxine cytotoxicity and deregulation of cell death-related genes in GR-M melanoma cells

open access: yesArhiv za Higijenu Rada i Toksikologiju, 2023
Anti-proliferative effects of halogenated boroxine – K2(B3O3F4OH) (HB) – have been confirmed in multiple cancer cell lines, including melanoma, but the exact mechanism of action is still unknown.
Elez-Burnjaković Nikolina   +8 more
doaj   +1 more source

Identifying chemicals based on receptor binding/bioactivation/mechanistic explanation associated with potential to elicit hepatotoxicity and to support structure activity relationship-based read-across

open access: yesCurrent Research in Toxicology, 2023
The liver is the most common target organ in toxicology studies. The development of chemical structural alerts for identifying hepatotoxicity will play an important role in in silico model prediction and help strengthen the identification of analogs used
Shengde Wu   +7 more
doaj   +1 more source

Two Cases of Ethylene Glycol Poisoning Treated Successfully with Haemodialysis [PDF]

open access: yesAsia Pacific Journal of Medical Toxicology, 2018
Introduction: Ethylene glycol is an organic toxic compound found in many household items including radiator coolants and brake oil. Toxic effects of ethylene glycol are due to its metabolites glycolic acid and oxalic acid which cause potentially fatal ...
Rukshanie De Silva   +3 more
doaj   +1 more source

Detail study on the interaction between perfluorooctanoic acid (PFOA) with human hemoglobin (Hb)

open access: yesCurrent Research in Toxicology, 2023
Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) are often referred to as legacy perfluoroalkyl substances (PFAS). Human exposure to PFAS leads to severe negative health impacts including cancers, infertility, and dysfunction in the
N.L. Dilani Perera   +3 more
doaj   +1 more source

hERG-toxicity prediction using traditional machine learning and advanced deep learning techniques

open access: yesCurrent Research in Toxicology, 2023
The rise of artificial intelligence (AI) based algorithms has gained a lot of interest in the pharmaceutical development field. Our study demonstrates utilization of traditional machine learning techniques such as random forest (RF), support-vector ...
Erik Ylipää   +6 more
doaj   +1 more source

Chaga mushroom triterpenoids as adjuncts to minimally invasive cancer therapies: A review

open access: yesCurrent Research in Toxicology, 2023
Cancer has become the second leading cause of death in the world. Integrative cancer therapy management is continuously evolving to enhance treatment outcomes.
Selina Plehn   +2 more
doaj   +1 more source

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