Results 41 to 50 of about 20,570 (99)

Investigation of in vitro biotransformation of tris (1-chloro-2-propyl) phosphate and confirmation in human urine

Current Research in Toxicology
Tris (1-chloro-2-propyl) phosphate (TCIPP) is one of the major organophosphate flame retardants present in the indoor and outdoor environment. Knowledge of biotransformation pathways is important to elucidate potential bioavailability and toxicity of ...
Fatima den Ouden, Andrea Estévez-Danta, Lidia Belova, Celine Gys, Anna Klimowska, Maarten Roggeman, Natan Van Wichelen, José Benito Quintana, Rosario Rodil, Giulia Poma, Adrian Covaci   +10 more
doaj   +1 more source

Long noncoding RNA TMPO-AS1 accelerates glycolysis by regulating the miR-1270/PKM2 axis in colorectal cancer

BMC Cancer
Long noncoding RNA thymopoietin-antisense RNA 1 (TMPO-AS1) is recognized as a participant in cancer progression. Nevertheless, its biological function in colorectal cancer remains obscure and needs further elucidation.
Yingmin Jin, Aimin Jiang, Liying Sun, Yue Lu   +3 more
semanticscholar   +1 more source

Protective effects of amphetamine and methylphenidate against dopaminergic neurotoxicants in SH-SY5Y cells

Current Research in Toxicology
Full treatment of the second most common neurodegenerative disorder, Parkinson’s disease (PD), is still considered an unmet need. As the psychostimulants, amphetamine (AMPH) and methylphenidate (MPH), were shown to be neuroprotective against stroke and ...
Patrícia Carneiro, Mariana Ferreira, Vera Marisa Costa, Félix Carvalho, João Paulo Capela   +4 more
doaj   +1 more source

Metformin regulates the proliferation and motility of melanoma cells by modulating the LINC00094/miR-1270 axis

Cancer Cell International
Melanoma is an aggressive tumor with a high mortality rate. Metformin, a commonly prescribed diabetes medication, has shown promise in cancer prevention and treatment.
Kuo-Wang Tsai, Jia-Bin Liao, Hui-Wen Tseng   +2 more
semanticscholar   +1 more source

In vitro-in silico study on the influence of dose, fraction bioactivated and endpoint used on the relative potency value of pyrrolizidine alkaloid N-oxides compared to parent pyrrolizidine alkaloids

Current Research in Toxicology
Pyrrolizidine alkaloids (PAs) and their N-oxides (PA-N-oxides) are phytotoxins found in food, feed and the environment. Yet, limited data exist from which the relative potency of a PA-N-oxide relative to its corresponding PA (REPPANO to PA) can be ...
Yasser Alhejji, Frances Widjaja, Shenghan Tian, Thomas Hoekstra, Sebastiaan Wesseling, Ivonne M.C.M. Rietjens   +5 more
doaj   +1 more source

The homologous tumor‐derived‐exosomes loaded with miR‐1270 selectively enhanced the suppression effect for colorectal cancer cells

Cancer Medicine
Colorectal cancer (CRC), known as prevalent cancer, has risen to be the leading cause of cancer‐related death. Engineered exosomes had attracted much attention since they acted as carriers to deliver small molecule drugs, therapeutic nucleic acids, and ...
Yingmin Jin, Liying Sun, Yingying Chen, Yue Lu   +3 more
semanticscholar   +1 more source

Acceleration of benzo(a)pyrene-induced colon carcinogenesis by Western diet in a rat model of colon cancer

Current Research in Toxicology
Colorectal cancer (CRC) is the third leading cause of cancer-related mortalities in the USA and around 52,550 people were expected to die from this disease by December 2023.
Kelly L. Harris, Kenneth J. Harris, Leah D. Banks, Samuel E. Adunyah, Aramandla Ramesh   +4 more
doaj   +1 more source

HELP: a catalogue of 170 million objects, selected at 0.36–4.5 μm, from 1270 deg2 of prime extragalactic fields [PDF]

Monthly notices of the Royal Astronomical Society, 2019
We present an optical to near-infrared (NIR) selected astronomical catalogue covering 1270 deg2. This is the first attempt to systematically combine data from 23 of the premier extragalactic survey fields – the product of a vast investment of telescope
R. Shirley, Y. Roehlly, P. Hurley, V. Buat, M. C. C. Campos Varillas, S. Duivenvoorden, K. Duncan, A. Efstathiou, D. Farrah, E. González Solares, K. Małek, L. Marchetti, I. McCheyne, A. Papadopoulos, E. Pons, R. Scipioni, Mattia Vaccari, S. Oliver   +17 more
semanticscholar   +1 more source

Investigating open access new approach methods (NAM) to assess biological points of departure: A case study with 4 neurotoxic pesticides

Current Research in Toxicology
Open access new approach methods (NAM) in the US EPA ToxCast program and NTP Integrated Chemical Environment (ICE) were used to investigate activities of four neurotoxic pesticides: endosulfan, fipronil, propyzamide and carbaryl.
Marilyn H. Silva
doaj   +1 more source

Phytochemical Screening, Antioxidant Activity, and Acute Toxicity Evaluation of Senna italica Extract Used in Traditional Medicine

Journal of Toxicology, 2023
Medicinal plants such as Senna italica are increasingly used for their purgative virtues to treat stomach aches, fever, and jaundice. This study aims to screen the phytochemical compounds and to assess the antioxidant activity in vitro and the acute oral
Rodrigue Towanou, Basile Konmy, Mahudro Yovo, Christian C. Dansou, Victorien Dougnon, Frédéric S. Loko, Casimir D. Akpovi, Lamine Baba-Moussa   +7 more
doaj   +1 more source