Results 51 to 60 of about 19,636 (99)

Toxicity of poly-dispersed single-walled carbon nanotubes on bone marrow derived Hematopoietic Stem and Progenitor Cells

open access: yesCurrent Research in Toxicology, 2021
This study has explored the effect of acid-functionalized single-walled carbon nanotubes (AF-SWCNTs) on Hematopoietic Stem and Progenitor Cell (HSPCs) in mouse bone marrow.
Md. Babu Mia, Rajiv K. Saxena
doaj  

Circular RNA Cdr1as sensitizes bladder cancer to cisplatin by upregulating APAF1 expression through miR‐1270 inhibition

open access: yesMolecular Oncology, 2019
Circular RNAs (circRNAs) have recently emerged as essential regulators in carcinogenesis and cancer progression. Previous studies have shown that Cdr1as functions as a microRNA (miRNA) sponge in various cancer types.
Wenbo Yuan   +13 more
semanticscholar   +1 more source

Excessive use of disinfectants against COVID-19 posing a potential threat to living beings

open access: yesCurrent Research in Toxicology, 2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan city of China in late December 2019 and identified as a novel coronavirus disease 2019 (COVID-19).
Dawood Ghafoor   +4 more
doaj  

In utero and lactational PCB exposure drives anatomic changes in the juvenile mouse bladder

open access: yesCurrent Research in Toxicology, 2021
Bladder dysfunction, including incontinence, difficulty emptying the bladder, or urgency to urinate is a pervasive health and quality of life concern. However, risk factors for developing these symptoms are not completely understood, and the influence of
Kimberly P. Keil Stietz   +11 more
doaj  

Interpretation of murine local lymph node assay (LLNA) data for skin sensitization: Overload effects, danger signals and chemistry-based read-across

open access: yesCurrent Research in Toxicology, 2021
There is a large body of information on testing of chemicals for skin sensitization in the murine local lymph node assay (LLNA), in which potency is quantified by the EC3 value, derived from dose-response data.
David W. Roberts
doaj  

Use of a rapid human primary cell-based disease screening model, to compare next generation products to combustible cigarettes

open access: yesCurrent Research in Toxicology, 2021
A growing number of public health bodies, regulators and governments around the world consider electronic vapor products a lower risk alternative to conventional cigarettes.
Liam Simms   +10 more
doaj  

Pre-clinical drug-drug interaction (DDI) of gefitinib or erlotinib with Cytochrome P450 (CYP) inhibiting drugs, fluoxetine and/or losartan

open access: yesCurrent Research in Toxicology, 2021
Objective: To evaluate drug-drug interactions (DDIs) between gefitinib or erlotinib with fluoxetine, and/or losartan. Methods: Human pooled microsomes, supersomes, and cryopreserved human hepatocytes were used to monitor DDIs in vitro.
Thu-Lan T. Luong   +4 more
doaj  

In vitro prediction of clinical signs of respiratory toxicity in rats following inhalation exposure

open access: yesCurrent Research in Toxicology, 2021
To date there are no OECD validated alternative approaches to study toxicity following inhalation exposure to airborne chemicals. The available OECD test guidelines for acute inhalation toxicity aim to estimate a value of the lethal air concentration of ...
E. Da Silva   +4 more
doaj  

Upregulation of microRNA-1270 suppressed human glioblastoma cancer cell proliferation migration and tumorigenesis by acting through WT1

open access: yesOncoTargets and Therapy, 2019
Background Glioblastoma multiforme (GBM) is one of the most aggressive brain tumors among human beings. In this study, we explored the functions of human microRNA-1270 (hsa-miR-1270) on GBM cancer cell proliferation, migration, and tumorigenesis ...
Lai Wei   +4 more
semanticscholar   +1 more source

Experimental study of hydrocarbon refrigerant (R-1270) to replace R-32 in residential air conditioning system

open access: yesJournal of Physics: Conference Series, 2020
The purpose of this study was to test the performance of hydrocarbon refrigerant (R-1270) to replace R-32 refrigerant. The refrigerant R1270 is a propylene-base refrigerant (C3H6), while R32 is a synthetic refrigerant.
K. Sumardi, N. Nahadi, M. Mutaufiq
semanticscholar   +1 more source

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