Results 61 to 70 of about 20,570 (99)

ICH S1 prospective evaluation study: weight of evidence approach to predict outcome and value of 2-year rat carcinogenicity studies. A report from the regulatory authorities subgroup

Frontiers in Toxicology
Introduction: The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) initiated a process in 2012 to revise the S1B Guideline “Testing for Carcinogenicity of Pharmaceuticals”.
Todd Bourcier, Timothy McGovern, Tania Cavaliero, Geoffrey Ebere, Akiyoshi Nishikawa, Jihei Nishimura, Kumiko Ogawa, Markku Pasanen, Alisa Vespa, Jan Willem Van der Laan   +9 more
doaj   +1 more source

Third-generation antivenomics analysis of the preclinical efficacy of Bothrofav® antivenom towards Bothrops lanceolatus venom

Toxicon: X, 2019
Bothrops lanceolatus inflicts severe envenomings in the Lesser Caribbean island of Martinique. Bothrofav®, a monospecific antivenom against B. lanceolatus venom, has proven highly effective at the preclinical and clinical levels.
Davinia Pla, Yania Rodríguez, Dabor Resiere, Hossein Mehdaoui, José María Gutiérrez, Juan J. Calvete   +5 more
doaj   +1 more source

Polyserositis: An Unusual Complication of Aluminum Phosphide Poisoning [PDF]

Asia Pacific Journal of Medical Toxicology, 2012
Background: Aluminum phosphide is the common cause of poisoning in adults in India, with a very high case fatality ratio. We studied five patients of aluminum phosphide poisoning with polyserositis.
Ashish Bhalla, Sushil Mahi, Navneet Sharma, Surjit Singh   +3 more
doaj  

Upregulation of microRNA-1270 suppressed human glioblastoma cancer cell proliferation migration and tumorigenesis by acting through WT1

OncoTargets and Therapy, 2019
Background Glioblastoma multiforme (GBM) is one of the most aggressive brain tumors among human beings. In this study, we explored the functions of human microRNA-1270 (hsa-miR-1270) on GBM cancer cell proliferation, migration, and tumorigenesis ...
Lai Wei, Pan Li, Chunjing Zhao, Na Wang, Na Wei   +4 more
semanticscholar   +1 more source

The DaNa projects: public communication of (nano)material safety data—from conspiracy theories to study quality

Frontiers in Toxicology
In this perspective, the authors give their view on the developments and experiences on communicating on (nano)materials safety. We would like to share our experiences with the scientific community in order to make them useful for future communication ...
Dana Kühnel, Harald F. Krug, Christoph Steinbach, Katja Nau   +3 more
doaj   +1 more source

Physiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in Rats

Journal of Toxicology, 2012
Bromochloromethane (BCM) is a volatile compound and a by-product of disinfection of water by chlorination. Physiologically based pharmacokinetic (PBPK) models are used in risk assessment applications.
W. S. Cuello, T. A. T. Janes, J. M. Jessee, M. A. Venecek, M. E. Sawyer, C. R. Eklund, M. V. Evans   +6 more
doaj   +1 more source

Stroke risk following bee and wasp stings: a systematic review of ischemic and hemorrhagic events

Frontiers in Toxicology
BackgroundEach year, approximately 100 million cases of bee and wasp stings are re-ported globally, with the majority resulting in mild reactions. However, in rarer instances, these stings can lead to severe and potentially fatal outcomes, including ...
Jorge Vasconez-Gonzalez, Juan S. Izquierdo-Condoy, Karen Delgado-Moreira, María de Lourdes Noboa-Lasso, Esteban Gamez-Rivera, Camila Salazar-Santoliva, María Belén Lopez-Molina, Esteban Ortiz-Prado   +7 more
doaj   +1 more source

Optimization on Reducing Slag Entrapment in 150 × 1270 mm Slab Continuous Casting Mold

Materials, 2019
To reduce slag entrapment in 150 × 1270 mm slab continuous casting molds at the Tang Steel Company, the effect of submerged entrance nozzle (SEN) depth and casting speed on the phenomenon was studied by computational fluid dynamics simulations. Then, the
Yang Wang, Shufeng Yang, Feng Wang, Jing-she Li   +3 more
semanticscholar   +1 more source

Pooled analysis of 1270 infective endocarditis cases in Turkey.

Journal of Infection in Developing Countries, 2019
INTRODUCTION Despite developments in medicine, infective endocarditis (IE) is still associated with significant morbidity and mortality. In this study it was aimed to systematically review the infective endocarditis literature published or presented from
Arman Vahabi, Funda Gül, Sabina Garakhanova, H. Sipahi, O. Sipahi   +4 more
semanticscholar   +1 more source

Bioprospection of rattlesnake venom peptide fractions with anti-adipose and anti-insulin resistance activity in vitro

Toxicon: X
Animal venoms are natural products that have served as a source of novel molecules that have inspired novel drugs for several diseases, including for metabolic diseases such as type-2 diabetes and obesity. From venoms, toxins such as exendin-4 (Heloderma
David Meléndez-Martínez, Erika Ortega-Hernández, Edwin Estefan Reza-Zaldívar, Alejandro Carbajal-Saucedo, Gustavo Arnaud-Franco, Ana Gatica-Colima, Luis Fernando Plenge-Tellechea, Marilena Antunes-Ricardo, Daniel A. Jacobo-Velázquez, Karla Mayolo-Deloisa, Omar Lozano, Marco Rito-Palomares, Jorge Benavides   +12 more
doaj   +1 more source