Results 151 to 160 of about 2,629,855 (234)
Advanced Science, EarlyView.A new class of biohybrid spheroids is engineered through the self‐assembly of adherent cells and extracellular matrix‐mimetic hydrogel microparticles (microgels). By mimicking a snowballing effect, this approach enables scalable formation of porous, millimeter‐scale spheroids with enhanced cell viability and molecular diffusion.
Zaman Ataie +7 more
wiley +1 more source
Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy
Advanced Science, EarlyView.A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann +15 more
wiley +1 more source
Machine Learning for Green Solvents: Assessment, Selection and Substitution
Advanced Science, EarlyView.Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta +4 more
wiley +1 more source
Clinical Use of Auto-ascites Re-infusion After Purification
Huli yanjiu, 2001 Based on hemodialysis principles,purified auto-ascites re-infusion was carried out in 11 cases of chronic renal failure（CRF） complicated with severe ascites and blood purification were conducted simultaneously.Ascites of the patients was re-infused into ...
杨惠敏 +8 more
doaj
Initial micropropagation strawberryFragaria annaninaL. from seed [PDF]
, 2017 In this study, we propagate shoots ofFragaria ananassa L.in vitrofrom seed by some kinds of cytokinin including BA (0.2-1.2 mg/L) or 2-ip (0.2-1.2 mg/L) or kinetin (0.2-1.2 mg/L). After 4 weeks, shoots are changed into root
Bùi Thị Thu Hằng +1 more
core +1 more source
Advanced Science, EarlyView.Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang +3 more
wiley +1 more source
Risk Management and Healthcare PolicyFred Kusumoto,1 Jacqueline Ross,2 Dan Wright,2 Richard A Chazal,3 Richard E Anderson2 1Heart Rhythm Service, Department of Cardiovascular Disease, Mayo Clinic, Jacksonville, FL, USA; 2The Doctors Company, Napa, CA, USA; 3Lee Health Heart and Vascular ...
Kusumoto F +4 more
doaj
NHÂN GIỐNG IN VIVO CÂY BÁCH BỆNH (EURYCOMA LONGIFOLIA JACK) [PDF]
, 2018 Tóm tắt: Bài báo này trình bày các nghiên cứu về nhân giống cây bách bệnh (Eurycoma longifolia Jack) bằng kỹ thuật giâm hom và gieo hạt. Hom giâm trước khi xử lý chất kích thích sinh trưởng đã được ngâm trong dung dịch diệt nấm Benlat-C 0,1 %.
Hợi, Nguyễn +3 more
core +1 more source
Advanced Science, EarlyView.This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source