Results 101 to 110 of about 6,086 (138)

Hyperactivation of RAB5 disrupts the endosomal Rab cascade leading to endolysosomal dysregulation in Down syndrome: A necessary role for increased APP gene dose. [PDF]

Alzheimers Dement
Chen XQ, Zuo X, Becker A, Mobley WC.
europepmc   +1 more source

Singapore grouper iridovirus utilizes Rab1 to facilitate viral trafficking and evade the immune response by targeting the STING-IRF3 pathway. [PDF]

Cell Commun Signal
Guan L, Zhang X, Xu Z, Li Y, Zhang L, Wang H, Zhang Z, Wei X, Liu Y, Qin Q, Wang S.   +10 more
europepmc   +1 more source

Allosteric inhibition of RAN decreases miR-126 biogenesis in endothelial cells and controls acute myeloid leukemia growth. [PDF]

Commun Biol
Valerio M, Wei W, Kang H, Ma N, Bhattacharya S, Baker G, Hu W, Zhang L, Hoang DH, Feng J, Zhang H, Zhang B, Perry JJP, Vaidehi N, Nguyen LXT, Marcucci G.   +15 more
europepmc   +1 more source

TDP-43 Regulates Rab4 Levels to Support Synaptic Vesicle Recycling and Neuromuscular Connectivity in <i>Drosophila</i> and Human ALS Models. [PDF]

Int J Mol Sci
Gbadamosi M, Romano G, Simbula M, Canarutto G, Ottoboni L, Corti S, Feiguin F.   +6 more
europepmc   +1 more source

Lipid-anchored melanotransferrin mediates transferrin-independent iron uptake and ferritin storage in mammals. [PDF]

Cell Death Discov
Tian MM, Tiong JWC, Gabathuler R, Martens G, Humphrey EC, Jefferies WA.   +5 more
europepmc   +1 more source

Antisense oligonucleotides directed against App and Rab5 normalized endosomal Rab activity and reversed DS-AD-linked degenerative phenotypes in the Dp16 mouse model of Down syndrome. [PDF]

Alzheimers Dement
Chen XQ, Zuo X, Becker A, Mante M, Florio JB, Jadhav SG, Albay R, Johnstone A, Karachentsev D, Rissman R, Zhao H, Dowdy SF, Mobley WC.   +12 more
europepmc   +1 more source

Plasma membrane mediated GLUT10 mitochondrial targeting regulates intracellular ascorbic acid homeostasis. [PDF]

iScience
Chirackal Jose A, Syu YW, Lai HW, Tsai MY, Jiang YF, Hsu SC, Lin PY, Huang WC, Chu WC, Fu CY, Lee YC.   +10 more
europepmc   +1 more source

Mechanistic adaptation of the metazoan RabGEFs Mon1-Ccz1 and Fuzzy-Inturned. [PDF]

Sci Adv
Wilmes S, Tönjes J, Drechsler M, Ruf A, Schäfer JH, Lürick A, Januliene D, Apelt S, Di Iorio D, Wegner SV, Loose M, Moeller A, Paululat A, Kümmel D.   +13 more
europepmc   +1 more source

A pan-viral map of host dependency factors from multi-omics integration and machine learning across influenza A, SARS-CoV-2, Zika, and dengue viruses. [PDF]

J Transl Med
Naseri M, Hiemisch A, Dietz A, Oswald M, Koenig R.   +4 more
europepmc   +1 more source

Targeting endosomal trafficking-mediated antigen escape to resensitize myeloma to CAR-T therapy. [PDF]

J Immunother Cancer
Wang Z, Wang G, Liu Y, Zhao Y, Guo S, Yang Y, Zhang Q, Hu C, Chang S, Wu X, An D, Hu H, Cai H, Zhang L, Shi J.   +14 more
europepmc   +1 more source