Results 131 to 140 of about 171,892 (231)

HP1c regulates development and gut homeostasis by suppressing Notch signaling through Su(H). [PDF]

open access: yesEMBO Rep, 2021
Sun J   +24 more
europepmc   +1 more source

Hydrogel‐Based Airway‐on‐Tube With Perfusable Endothelial Lumen and Outward Epithelialization

open access: yesAdvanced Materials, EarlyView.
A hydrogel‐based airway‐on‐tube platform featuring a perfusable endothelial lumen and outward epithelialization is presented. The system supports primary human bronchial epithelial and lung microvascular endothelial coculture under air‐liquid interface conditions.
Ali Doryab   +8 more
wiley   +1 more source

HP1γ promotes the progression of colorectal cancer through interaction with RBPJ of the Notch signaling pathway. [PDF]

open access: yesCell Biol Toxicol
Zhu RB   +22 more
europepmc   +1 more source

Microgels Enable iPSCs to Assemble, Expand, and Differentiate Into Organoids—From Sizable to High‐Throughput

open access: yesAdvanced Materials, EarlyView.
A chemically defined PEG‐based microgel platform enables scalable, reproducible production of three‐dimensional microgel‐iPSC constructs in multiple sizes. The system is compatible with high‐throughput automation and supports human iPSC expansion and differentiation within a single construct, including directed differentiation into cardiac organoids ...
Laura Klasen   +8 more
wiley   +1 more source

Biohybrid Crawling Robot With Spiral‐Spring Backbone and Inclined Legs for Enhanced Locomotion

open access: yesAdvanced Materials, EarlyView.
We present a biohybrid crawling robot integrating a muscle ring with a flexible skeleton combining two complementary structural elements. The spiral‐spring backbone enables large‐amplitude bending without compromising axial stability, while outward‐inclined legs with unequal front–rear lengths effectively convert deformation into directional strides ...
Tomohiro Morita   +2 more
wiley   +1 more source

A Retinal Matrix Stiffening Model Reveals FAK‐Dependent Mechanotransduction in Pericytes Underlies Vascular Destabilization

open access: yesAdvanced Materials, EarlyView.
In this study, we show that retinal matrix stiffness is increased in diabetic mice. Using engineered human vascular models with controlled matrix stiffness, we demonstrate that stiffening activates focal adhesion kinase (FAK) signaling in pericytes, suppresses Notch signaling, and disrupts vascular morphology.
Emily Warren   +6 more
wiley   +1 more source

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