Shared Human/Rabbit Ligands for Rabbit Hemorrhagic Disease Virus
To the Editor: Rabbit hemorrhagic disease virus (RHDV) is a calicivirus of the genus Lagovirus that causes epidemics of an acute disease and mortality rates of 50%–90% among rabbits. The disease, which was first described in 1984, is characterized by hemorrhagic lesions, mainly affecting the liver and lungs 24–72 h after infection (1).
Kristina Nyström +3 more
doaj +3 more sources
Changes in MicroRNA Expression during Rabbit Hemorrhagic Disease Virus (RHDV) Infection [PDF]
Current knowledge on the role of microRNAs (miRNAs) in rabbit hemorrhagic disease virus (RHDV) infection and the pathogenesis of rabbit hemorrhagic disease (RHD) is still limited.
Beata Hukowska-Szematowicz +6 more
doaj +2 more sources
Rabbit Hemorrhagic Disease Virus Isolated from Diseased Alpine Musk Deer (Moschus sifanicus) [PDF]
Rabbit hemorrhagic disease virus (RHDV) is the causative agent of rabbit hemorrhagic disease (RHD), and its infection results in mortality of 70–90% in farmed and wild rabbits. RHDV is thought to replicate strictly in rabbits.
Shijun Bao +8 more
doaj +3 more sources
Emerging Rabbit Hemorrhagic Disease Virus 2 (RHDVb), Australia
To the Editor: In May 2015 an isolate of the recently emerged variant of rabbit hemorrhagic disease virus (RHDV), RHDV2, was identified in an Australian wild rabbit (Oryctolagus cuniculus). RHDV2 (also called RHDVb) was first described in outbreaks in France in 2010 (1), then Italy and Spain in 2011 (2,3) and in Portugal from 2012 onwards (4).
Robyn N. Hall +5 more
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Structural Basis for Rabbit Hemorrhagic Disease Virus Antibody Specificity. [PDF]
Isolated RHDV antibodies have been used for decades to distinguish between antigenic variants, monitor temporal capsid evolution, and examine neutralizing capacities. In this study, we provided the structural basis for an RHDV GI.2 specific diagnostic antibody (2D9) binding and reveal that a small number of amino acid substitutions at the binding site ...
Leuthold MM +6 more
europepmc +3 more sources
A Brief Update on Rabbit Hemorrhagic Disease Virus [PDF]
Lorenzo Capucci, Antonio Lavazza
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Processing of rabbit hemorrhagic disease virus polyprotein [PDF]
Expression of rabbit hemorrhagic disease virus (RHDV) cDNAs in vitro with rabbit reticulocyte lysates and in Escherichia coli have been used to study the proteolytic processing of RHDV polyprotein encoded by ORF1. An epitope tag was used for monitoring the gene products by a specific antibody. We have identified four gene products with molecular masses
J M, Martín Alonso +3 more
openaire +2 more sources
Rabbit hemorrhagic disease virus type 2 epidemic in a rabbit colony in Japan. [PDF]
Twenty-three of 42 European rabbits (Oryctolagus cuniculus), belonging to the same rabbit colony, died in March 2020 (55% mortality) in Chiba prefecture, Japan. The disease course was extremely acute without indicators of death or hemorrhage. Necropsy revealed liver swelling, discoloration, cloudiness and fragility, and pulmonary edema. Histologically,
Fukui H +4 more
europepmc +3 more sources
An outbreak of rabbit hemorrhagic disease (RHD) caused by Lagovirus europaeus GI.2/rabbit hemorrhagic disease virus 2 (RHDV2) in Ehime, Japan. [PDF]
A total of ten 1-2-year-old rabbits died within 2 weeks at a facility in Ehime prefecture in May 2019. Necropsy revealed liver discoloration and fragility, hemorrhage of some organs and blood coagulation failure. On histopathologic examination, necrotizing hepatitis was a common finding, together with fibrin thrombi in the small vessels and hemorrhage ...
Katayama A +4 more
europepmc +3 more sources
Facts about Wildlife Diseases: Rabbit Hemorrhagic Disease Virus Serotype 2 (RHDV2)
This publication provides information on rabbit hemorrhagic disease virus serotype 2 (RHDV2) and discusses infection, clinical signs, treatment, prevention, and reporting. Written by Catherine E. Dixon and Juan M.
Catherine E. Dixon +1 more
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