Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The retention of S35-labelled bovine serum albumin on normal and immunized rabbit liver tissue [PDF]
, 1957 The S35-label of S35-BSA was detected in the liver tissue of rabbits to the extent of 0.02 per cent (10 µg or sime 1014 molecules) of the injected material at 140 days after injection.
Campbell, Dan H., Garvey, Justine S.
core +2 more sources
On Sharing, Memoization, and Polynomial Time (Long Version) [PDF]
, 2015 We study how the adoption of an evaluation mechanism with sharing and memoization impacts the class of functions which can be computed in polynomial time. We first show how a natural cost model in which lookup for an already computed value has no cost is
Avanzini, Martin, Lago, Ugo Dal
core +6 more sources
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Effects of different time schedules for regrouping on socio-positive behaviors in group-housed rabbit does [PDF]
Kafkas Universitesi Veteriner Fakültesi DergisiMany studies have demonstrated that group housing of does often results in aggression and sometimes lesions due to biting. However, the positive interactions among reproducing does in group housing systems is less clear.
Metin PETEK, Sabine G. GEBHARDT-HENRICH
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Modelling for research on chemical control of mammals in New Zealand [PDF]
, 1974 Development of predictive formulae or qualitative statements about the probable outcome of control campaigns entails knowledge of bait quality and distribution, behaviour, vagaries of weather at the time of the control campaign, and other factors which ...
Batcheler, C. L., Bell, J.
core +1 more source
Pulmonary Bovine-Type Tuberculosis in Rabbits: Bacillary Virulence, Inhaled Dose Effects, Tuberculin Sensitivity, andMycobacterium vaccaeImmunotherapy [PDF]
, 1998 Paul J. Converse +10 more
openalex +1 more source