Results 41 to 50 of about 18,349 (180)

A Phase 2 Trial of Frexalimab, a CD40L Antagonist, in Adolescents and Adults With Recent‐Onset Type 1 Diabetes (FABULINUS): Rationale and Study Design

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Type 1 diabetes (T1D) is a chronic autoimmune disease, characterised by progressive destruction of the insulin‐producing pancreatic β‐cells. Preserving remaining β‐cells at the time of diagnosis may improve long‐term outcomes. Frexalimab is a humanised monoclonal antibody specific for CD40L undergoing evaluation for treatment of ...
Andriy Cherkas   +11 more
wiley   +1 more source

A novel ELISA for quantification of glycoprotein in human rabies vaccines using a clinically proven virus neutralizing human monoclonal antibody

open access: yesHuman Vaccines & Immunotherapeutics, 2020
Global efforts on the replacement of the in vivo rabies vaccine potency test (NIH method) with in vitro methods for quantification of immunodominant glycoprotein (GP) in rabies vaccine have made significant progress.
Sunil Gairola   +2 more
doaj   +1 more source

Biochemistry and Clinical Biochemistry Department, Faculty of Veterinary Medicine, Benha University [PDF]

open access: yesBenha Veterinary Medical Journal, 2016
Aiming to raise the levels of immunity induced in dogs by the cell culture inactivated rabies vaccine, bee venom BV wassubjected to investigate its immune stimulant effect in vaccinated dogs.
Khodeir H.   +3 more
doaj   +1 more source

Physiological and behavioural effects of continuous remifentanil‐xylazine administration in donkeys

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Remifentanil and xylazine are used as continuous infusions to facilitate standing surgery in horses. Their use for this purpose has not been reported in donkeys. Objectives To evaluate the behavioural, sedative, and cardiorespiratory effects of continuous intravenous infusion of remifentanil and xylazine in donkeys. Study Design Non‐
Kássia Fernanda Araújo Damasceno   +6 more
wiley   +1 more source

Oral vaccination of wildlife using a vaccinia–rabies-glycoprotein recombinant virus vaccine (RABORAL V-RG®): a global review

open access: yesVeterinary Research, 2017
RABORAL V-RG® is an oral rabies vaccine bait that contains an attenuated (“modified-live”) recombinant vaccinia virus vector vaccine expressing the rabies virus glycoprotein gene (V-RG).
Joanne Maki   +13 more
doaj   +1 more source

Barriers to Canine Rabies Vaccination in Nigeria: Implications for Rabies Elimination by 2030

open access: yesZoonoses and Public Health, EarlyView.
ABSTRACT Introduction Mass dog rabies vaccination is the most effective strategy for preventing human rabies and interrupting transmission. However, achieving high vaccination coverage in dog populations remains challenging in many low‐ and middle‐income countries (LMICs), due to multiple barriers.
Philip P. Mshelbwala   +8 more
wiley   +1 more source

An Open‐Source Systematic Reviews Integrated System (OSSYRIS) – Streamlining Processes and Standardising Data Structures

open access: yesCochrane Evidence Synthesis and Methods, Volume 4, Issue 4, July 2026.
ABSTRACT Introduction Carrying out a systematic review (SR) of the literature entails a high workload and encompasses a variety of very different tasks. The emergence of artificial intelligence tools has brought further opportunities to improve the efficiency and reliability of SRs.
Xavier Bosch‐Capblanch   +8 more
wiley   +1 more source

Harvest increase and culling as tools for managing chronic wasting disease in white‐tailed deer

open access: yesThe Journal of Wildlife Management, Volume 90, Issue 5, July 2026.
We used an agent‐based model to simulate the effect of CWD management on a white‐tailed deer population in northwest Indiana and northeast Illinois. Our results suggest that wildlife managers should reconsider how and if they should manage CWD. Abstract Chronic wasting disease (CWD), a transmissible spongiform encephalopathy that affects white‐tailed ...
Jonathan D. Brooks   +3 more
wiley   +1 more source

Engineering Extracellular Vesicles for Anti‐Aging Therapy: Mechanisms, Applications, and Perspectives

open access: yesAging Cell, Volume 25, Issue 7, July 2026.
This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang   +6 more
wiley   +1 more source

Management of Severe Penile and Scrotal Degloving Injury Following Dog Bite in an Infant: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Dog bites are a common cause of pediatric trauma, although genital involvement is rare and presents significant reconstructive challenges. We report a 7‐month‐old male infant with severe penile and scrotal degloving injury and distal urethral involvement following a domestic dog bite.
Denis Mucunguzi   +5 more
wiley   +1 more source

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