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Development of mRNA rabies vaccines [PDF]

Human Vaccines & Immunotherapeutics
Rabies, primarily transmitted to humans by dogs (accounting for 99% of cases). Once rabies occurs, its mortality rate is approximately 100%. Post-exposure prophylaxis (PEP) is critical for preventing the onset of rabies after exposure to rabid animals ...
Zixin Fang, Pengcheng Yu, Wuyang Zhu
doaj   +5 more sources

Potency of Veterinary Rabies Vaccines Marketed in Sri Lanka [PDF]

Vaccines, 2023
Seven brands of veterinary rabies vaccines are commercially available in Sri Lanka, but there is no established procedure to test the potency of the vaccines at the local level, especially prior to their release.
Hasanthi Rathnadiwakara, Mangala Gunatilake, Alexandre Servat, Marine Wasniewski, Jean-Christophe Thibault, Florence Cliquet   +5 more
doaj   +3 more sources

Developments in Rabies Vaccines: The Path Traversed from Pasteur to the Modern Era of Immunization [PDF]

Vaccines, 2023
Rabies is a disease of antiquity and has a history spanning millennia ever since the first interactions between humans and dogs. The alarming fatalities caused by this disease have triggered rabies prevention strategies since the first century BC.
Krithiga Natesan, Shrikrishna Isloor, Balamurugan Vinayagamurthy, Sharada Ramakrishnaiah, Rathnamma Doddamane, Anthony R. Fooks   +5 more
doaj   +3 more sources

Role of Oral Rabies Vaccines in the Elimination of Dog-Mediated Human Rabies Deaths [PDF]

Emerging Infectious Diseases, 2020
Domestic dogs are responsible for nearly all the »59,000 global human rabies deaths that occur annually. Numerous control measures have been successful at eliminating dog-mediated human rabies deaths in upper-income countries, including dog population ...
Ryan M. Wallace, Florence Cliquet, Christine Fehlner-Gardiner, Anthony R. Fooks, Claude T. Sabeta, Alvaro Aguilar Setién, Changchun Tu, Vlad Vuta, Boris Yakobson, Dong-Kun Yang, Gideon Brückner, Conrad M. Freuling, Lea Knopf, Artem Metlin, Patricia Pozzetti, Pebi Purwo Suseno, Sean V. Shadomy, Gregorio Torres, Marco Antonio Natal Vigilato, Bernadette Abela-Ridder, Thomas Müller   +20 more
doaj   +3 more sources

New Rabies Vaccines for Use in Humans [PDF]

Vaccines, 2019
Although vaccines are available, rabies still claims more than 55,000 human lives each year. In most cases, rabies vaccines are given to humans after their exposure to a rabid animal; pre-exposure vaccination is largely reserved for humans at high risk ...
Hildegund C. J. Ertl
doaj   +3 more sources

Current Rabies Vaccines Do Not Confer Protective Immunity against Divergent Lyssaviruses Circulating in Europe [PDF]

Viruses, 2019
The use of the rabies vaccine for post-exposure prophylaxis started as early as 1885, revealing a safe and efficient tool to prevent human rabies cases. Preventive vaccination is the basis for the control of canine-mediated rabies, which has already been
Juan E. Echevarría, Ashley C. Banyard, Lorraine M. McElhinney, Anthony R. Fooks   +3 more
doaj   +3 more sources

Composition of the murine gut microbiome impacts humoral immunity induced by rabies vaccines [PDF]

Clinical and Translational Medicine, 2020
Background Gut microbiome plays a crucial role in modulating human and animal immune responses. Rabies is a fatal zoonosis causing encephalitis in mammals and vaccination is the most effective method to control and eliminate rabies.
Yachun Zhang, Qiong Wu, Ming Zhou, Zhaochen Luo, Lei Lv, Jie Pei, Caiqian Wang, Benjie Chai, Baokun Sui, Fei Huang, Zhen F. Fu, Ling Zhao   +11 more
doaj   +3 more sources

Rabies vaccines and interferon [PDF]

Journal of Hygiene, 1972
SUMMARYSamples of Fermi, Semple, modified Semple, Duck embryo and tissue culture rabies vaccine were inoculated by different routes and in different doses into rabbits, mice and hamsters. The vaccines induced neither detectable interferon nor immediate protection against lethal challenge with CVS rabies virus.Under similar conditions, high but ...
G. S. Turner
openalex   +5 more sources

Inhibitory effect of concomitantly administered rabies immunoglobulins on the immunogenicity of commercial and candidate human rabies vaccines in hamsters [PDF]

Scientific Reports, 2022
The World Health Organization protocol for rabies post-exposure prophylaxis (PEP) recommends extensive wound washing, immediate vaccination, and administration of rabies immunoglobulin (RIG) in severe category III exposures.
Marie-Clotilde Bernard, Florence Boudet, Andrea-Clemencia Pineda-Peña, Françoise Guinet-Morlot   +3 more
doaj   +2 more sources

Evaluation of cost-effective strategies for rabies post-exposure vaccination in low-income countries [PDF]

, 2010
<b>Background:</b> Prompt post-exposure prophylaxis (PEP) is essential in preventing the fatal onset of disease in persons exposed to rabies.
A Ambrozaitis, A Goswami, BP Quiambao, C Wang, CE Rupprecht, CJL Murray, Deborah Briggs, DJ Briggs, DL Knobel, E Shim, EM Fevre, J Zinsstag, Jakob Zinsstag, K Hampson, K Hampson, Katie Hampson, L Brenzel, M Kaare, M Mallewa, M Song, MJ Warrell, MJ Warrell, MJ Warrell, MJ Warrell, MJ Warrell, MK Sudarshan, P Chulasugandha, P Khawplod, P Shantavasinkul, R Franka, S Cleaveland, S Ly, Sarah Cleaveland, SN Madhusudana, T Kamoltham, T Müller, UNICEF, WHO, WHO, WHO, WHO, WHO, WHO   +42 more
core   +44 more sources