Spatial expansions and travelling waves of rabies in vampire bats [PDF]
A major obstacle to anticipating the cross-species transmission of zoonotic diseases and developing novel strategies for their control is the scarcity of data informing how these pathogens circulate within natural reservoir populations.
Benavides, Julio A.+2 more
core +1 more source
Macaque models of human infectious disease. [PDF]
Macaques have served as models for more than 70 human infectious diseases of diverse etiologies, including a multitude of agents-bacteria, viruses, fungi, parasites, prions.
Abe+330 more
core +1 more source
An mRNA-based rabies vaccine induces strong protective immune responses in mice and dogs
Rabies is a lethal zoonotic disease that is mainly caused by the rabies virus (RABV). Although effective vaccines have long existed, current vaccines take both time and cost to produce. Messenger RNA (mRNA) technology is an emergent vaccine platform that
Jianglong Li+14 more
semanticscholar +1 more source
Tracheal collapse rates in Kenyan working cart and pack donkeys
Abstract Background Donkeys (Equus asinus) in East Africa are recognised as working with poorly designed harnesses and carts. The donkey cart used in regions of Africa, specifically Meru County, Kenya, appears to place the cart's weight solely on the donkey's mid‐cervical region.
Martha Mellish+3 more
wiley +1 more source
Lymph node but not intradermal injection site macrophages are critical for germinal center formation and antibody responses to rabies vaccination. [PDF]
UNLABELLED: Replication-deficient rabies virus (RABV)-based vaccines induce rapid and potent antibody responses via T cell-independent and T cell-dependent mechanisms. To further investigate early events in vaccine-induced antibody responses against RABV
Lytle, Andrew G+2 more
core +2 more sources
Flagellins as Vaccine Adjuvants and Cancer Immunotherapy: Recent Advances and Future Prospects
The figure depicts the role of flagellin in immune cells. Flagellin interacts with TLR5, resulting in the formation of homodimers and the recruitment of MyD88, which activates the IκB and MAPK signalling pathways. This results in the activation of NF‐κB and AP‐1, producing TNF‐α, IL‐6, IL‐8, and IL‐12.
Asma Talukder+4 more
wiley +1 more source
National Rabies Control Programme, India, is in operation since 2012–2013 without much impact due to poor funding and no set policy for the rabies prevention and control. An effort was made to develop a draft policy paper which can help the Government of
Mysore Kalappa Sudarshan+1 more
doaj +1 more source
Lyophilisation of influenza, rabies and Marburg lentiviral pseudotype viruses for the development and distribution of a neutralisation-assay based diagnostic kit [PDF]
Pseudotype viruses (PVs) are chimeric, replication-deficient virions that mimic wild-type virus entry mechanisms and can be safely employed in neutralisation assays, bypassing the need for high biosafety requirements and performing comparably to ...
Assar+44 more
core +3 more sources
Diverse hosts, diverse immune systems: Evolutionary variation in bat immunology
Bats are recognized to have distinct immune systems from other vertebrates that may allow them to host virulent pathogens without showing disease. However, these flying mammals are also incredibly diverse, such that bats should not be expected to be immunologically homogenous.
Daniel J. Becker+11 more
wiley +1 more source
Comparing Rabies Antibody Titres in Imported Dogs to a Population of Dogs in Ontario, Canada
ABSTRACT Introduction Vaccinating dogs against rabies virus is essential for protecting animal and public health. Most dogs imported into Canada must have a valid rabies vaccination certificate but do not require serological testing to confirm response to vaccination.
Catherine R. Belanger+4 more
wiley +1 more source