Results 131 to 140 of about 1,739,706 (302)

Recent optical approaches for anatomical and functional dissection of neuron–astrocyte circuitry

The Journal of Physiology, EarlyView.
Abstract figure legend This review summarises novel optical approaches to deciphering structural and functional wiring diagrams of neuron–astrocyte circuits in the brain. There are three groups: the anatomical proximity assay, transsynaptic viral tracing and the functional connection assay. The FRET‐based neuron–astrocyte proximity assay allows mapping
Yoshiki Hatashita, Takafumi Inoue
wiley   +1 more source

The Final (Oral Ebola) Vaccine Trial on Captive Chimpanzees? [PDF]

, 2017
Could new oral vaccine technologies protect endangered wildlife against a rising tide of infectious disease? We used captive chimpanzees to test oral delivery of a rabies virus (RABV) vectored vaccine against Ebola virus (EBOV), a major threat to wild ...
Goetzmann, Jason E., Hasselschwert, Dana L., Kurup, Drishya, Schnell, Matthias J., Walsh, Peter D., Wirblich, Christoph   +5 more
core   +2 more sources

In Vivo Cytosolic Delivery of Biomolecules into Neurons for Super‐Resolution Imaging and Genome Modification

Advanced Science, Volume 12, Issue 25, July 3, 2025.
The N1 peptide specifically targets neurons, enabling cytosolic delivery of fluorescent dyes and proteins for super‐resolution imaging and functional genetic modification. Abstract Efficient delivery of biomolecules into neurons has significant impacts on therapeutic applications in the central nervous system (CNS) and fundamental neuroscience research.
Xiaoqian Ge, Joseph B. Wekselblatt, Scott Elmore, Bo Wang, Tongtong Wang, Renjinming Dai, Tingting Zhang, Harsh Dave, Mohammadaref Ghaderi, Athul Raj Anilkumar, Bill Wang, Shashank R. Sirsi, Jung‐Mo Ahn, Mikhail G. Shapiro, Yuki Oka, Carlos Lois, Zhenpeng Qin   +16 more
wiley   +1 more source

Interaction of rabies virus P-protein with STAT proteins is critical to lethal rabies disease.

Journal of Infectious Diseases, 2014
BACKGROUND Rabies virus (RABV) causes rabies disease resulting in >55,000 human deaths/year. The multifunctional RABV P-protein has essential roles in genome replication, and forms interactions with cellular STAT proteins that are thought to underlie ...
L. Wiltzer, K. Okada, Satoko Yamaoka, F. Larrous, H. Kuusisto, M. Sugiyama, D. Blondel, H. Bourhy, D. Jans, N. Ito, G. Moseley   +10 more
semanticscholar   +1 more source

Lateral Thinking: Exploring the Lateral Entorhinal Cortex Projections to the Hippocampus in the Rodent Brain

Journal of Comparative Neurology, Volume 533, Issue 7, July 2025.
Localization and layers of the lateral entorhinal cortex. Photomicrographs depicting both coronal (A: 1–4) and sagittal (B: 5–8) sections from a mouse brain to show different perspectives of the entorhinal cortex inputs to the hippocampus (HC). Sections were stained with toluidine blue to aid with the visualization of the six layers of the lateral ...
Rebecca Przy, Mira M. M. Wade, Priscilla G. Welter, Patricia S. Brocardo, Brian R. Christie   +4 more
wiley   +1 more source

APRIL:TACI axis is dispensable for the immune response to rabies vaccination. [PDF]

, 2017
There is significant need to develop a single-dose rabies vaccine to replace the current multi-dose rabies vaccine regimen and eliminate the requirement for rabies immune globulin in post-exposure settings.
Alugupalli, Kishore R., Haley, Shannon L., Lytle, Andrew G., McGettigan, James P., Plummer, Joseph R., Tzvetkov, Evgeni P.   +5 more
core   +1 more source

A Recombinant Rabies Virus Encoding Two Copies of the Glycoprotein Gene Confers Protection in Dogs against a Virulent Challenge

PLoS ONE, 2014
The rabies virus (RABV) glycoprotein (G) is the principal antigen responsible for the induction of virus neutralizing antibodies (VNA) and is the major modality of protective immunity in animals.
Xiao-Hui Liu, Youtian Yang, Zhao-Jin Sun, J. Chen, Jun Ai, C. Dun, Z. Fu, Xuefeng Niu, Xiaofeng Guo   +8 more
semanticscholar   +1 more source

Phase Separation Regulates Metabolism, Mitochondria, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Mitochondrion‐related liquid–liquid phase separation. (1) Phase separation mediates the self‐assembly of mitochondrial nucleoids (mt‐nucleoids). (2) Phase segregation mediates the formation of mitochondrial RNA granules (MRGs). (3) Phase separation mediates the formation of mitochondrial degradosomes.
Chuan Gao, Peng Ding, Changqing Zhang, Junjie Gao   +3 more
wiley   +1 more source

Cultivation of Rabies Virus.

Experimental Biology and Medicine, 1937
Webster and Clow1 and Kanazawa2 reported the first success in cultivating rabies virus. The former accomplished this with a medium consisting of Tyrode solution containing normal monkey serum and minced mouse embryo brain, while the latter propagated the virus in Tyrode solution in the presence of rabbit embryo brain tissue, but without the addition of
E. W. Schultz, G. F. Williams
openaire   +2 more sources

Engineering, Expression in Transgenic Plants and Characterisation of E559, a Rabies Virus-Neutralising Monoclonal Antibody

Journal of Infectious Diseases, 2014
Rabies post-exposure prophylaxis (PEP) currently comprises administration of rabies vaccine together with rabies immunoglobulin (RIG) of either equine or human origin. In the developing world, RIG preparations are expensive, often in short supply, and of
C. V. van Dolleweerd, A. Y. Teh, A. Banyard, L. Both, H. C. T. Lotter-Stark, T. Tsekoa, Baby Phahladira, W. Shumba, E. Chakauya, C. Sabeta, Clemens Gruber, A. Fooks, R. Chikwamba, J. Ma   +13 more
semanticscholar   +1 more source