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Mechanisms of Rabies Virus Neutralization
Virology, 1993The number of immunoglobulins necessary to neutralize rabies virus (CVS strain) was estimated using IgG and IgM monoclonal antibodies (MAb) specific to the three antigenic sites of the glycoprotein. It was estimated that below 130 IgG or 30 IgM bound per virions, infectivity was totally preserved.
Yves Gaudin +3 more
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2003
Publisher Summary This chapter reviews the rabies virus structure, its molecular composition and morphology, its genome organization, and its genetic relationship to the structural proteins of the virus. The chapter discusses the current knowledge of the virus's life cycle (attachment, penetration, replication, assembly, and egress) in susceptible ...
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Publisher Summary This chapter reviews the rabies virus structure, its molecular composition and morphology, its genome organization, and its genetic relationship to the structural proteins of the virus. The chapter discusses the current knowledge of the virus's life cycle (attachment, penetration, replication, assembly, and egress) in susceptible ...
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Apoptosis and rabies virus neuroinvasion
Biochimie, 2003Rabies virus (RV) causes a non-lytic infection of neurons leading to a fatal myeloencephalitis in mammals including humans. By comparing the infection of the nervous system of mice by a highly pathogenic neuroinvasive strain of RV (CVS) and by a strain of attenuated pathogenicity (PV) with restricted brain invasion, we showed that RV neuroinvasiveness ...
Monique Lafon, Leïla Baloul
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Replication strategies of rabies virus
Virus Research, 2005Rabies virus (RV) is a prototype neurotropic virus that causes fatal disease in human and animals. RV infects hosts at the periphery, enters motoneurons or sensory nerves and moves to the central nervous system (CNS) via retrograde axonal transport. At later stages, there is also centrifugal spread to major exit portals, such as the salivary glands ...
Stefan Finke, Karl-Klaus Conzelmann
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Rabies Virus Infection and MicroRNAs
2011Endogenous RNA-silencing mechanisms have been shown to play a role in regulating viral and host processes during the course of infection. Such interactive processes may involve host cellular and/or viral-encoded microRNAs (miRNAs). Rabies is unique not only in terms of its invariably fatal course once disease signs develop, but it also has a variable ...
Aekkapol Mahavihakanont +2 more
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Rabies Virus Infection: An Update
Journal of Neurovirology, 2003There are still many unanswered questions in the pathogenesis of rabies, but recent progress has been made. During most of the long incubation period of rabies, the virus likely remains close the site of viral entry. Centripetal spread to the central nervous system and spread within the central nervous system occur by fast axonal transport.
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Trends in Neurosciences, 1985
Abstract The attachment of the spike glycoprotein of rabies virus to a cell surface constituent that is largely restricted to neurons may help explain the neurotropism of this virus. Rabies virus has been localized to regions containing a high density of ACh receptors at neuromuscular junctions and on cultured embryonic myotubes.
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Abstract The attachment of the spike glycoprotein of rabies virus to a cell surface constituent that is largely restricted to neurons may help explain the neurotropism of this virus. Rabies virus has been localized to regions containing a high density of ACh receptors at neuromuscular junctions and on cultured embryonic myotubes.
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Rabies Virus Transcription and Replication
2011Rabies virus (RABV) is a negative-stranded RNA virus. Its genome is tightly encapsidated by the viral nucleoprotein (N) and this RNA-N complex is the template for transcription and replication by the viral RNA-dependent RNA polymerase (L) and its cofactor, the phosphoprotein (P).
Danielle Blondel +2 more
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Purification of fixed rabies virus
Virology, 1965Abstract Rabies virus was purified approximately 240-fold by centrifugation and ECTE-OLA-cellulose chromatography. The virus could be eluted from the cellulose using 0.1 M KC1 in 0.01 M potassium phosphate buffer, pH 7.0. The use of 0.3 M KCl yielded more infective virus per volume of buffer and gave higher titers at the peak of elution. Infectivity
J. B. Thomas +3 more
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Rabies Virus Assembly and Budding
2011Rabies virus (RABV) and other negative-strand RNA viruses are the causes of serious diseases in humans and animals worldwide. Assembly and budding are important late events in the replication cycles of these negative-strand RNA viruses that have received much attention in the past decade.
Atsushi Okumura, Ronald N. Harty
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