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Replication strategies of rabies virus
Virus Research, 2005Rabies virus (RV) is a prototype neurotropic virus that causes fatal disease in human and animals. RV infects hosts at the periphery, enters motoneurons or sensory nerves and moves to the central nervous system (CNS) via retrograde axonal transport. At later stages, there is also centrifugal spread to major exit portals, such as the salivary glands ...
Stefan Finke, Karl-Klaus Conzelmann
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Rabies Virus Transcription and Replication
2011Rabies virus (RABV) is a negative-stranded RNA virus. Its genome is tightly encapsidated by the viral nucleoprotein (N) and this RNA-N complex is the template for transcription and replication by the viral RNA-dependent RNA polymerase (L) and its cofactor, the phosphoprotein (P).
Danielle Blondel +2 more
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Trends in Neurosciences, 1985
Abstract The attachment of the spike glycoprotein of rabies virus to a cell surface constituent that is largely restricted to neurons may help explain the neurotropism of this virus. Rabies virus has been localized to regions containing a high density of ACh receptors at neuromuscular junctions and on cultured embryonic myotubes.
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Abstract The attachment of the spike glycoprotein of rabies virus to a cell surface constituent that is largely restricted to neurons may help explain the neurotropism of this virus. Rabies virus has been localized to regions containing a high density of ACh receptors at neuromuscular junctions and on cultured embryonic myotubes.
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Purification of fixed rabies virus
Virology, 1965Abstract Rabies virus was purified approximately 240-fold by centrifugation and ECTE-OLA-cellulose chromatography. The virus could be eluted from the cellulose using 0.1 M KC1 in 0.01 M potassium phosphate buffer, pH 7.0. The use of 0.3 M KCl yielded more infective virus per volume of buffer and gave higher titers at the peak of elution. Infectivity
J. B. Thomas +3 more
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Rabies Virus Assembly and Budding
2011Rabies virus (RABV) and other negative-strand RNA viruses are the causes of serious diseases in humans and animals worldwide. Assembly and budding are important late events in the replication cycles of these negative-strand RNA viruses that have received much attention in the past decade.
Atsushi Okumura, Ronald N. Harty
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1985
Cell-mediated immunity plays a major role in pathogenicity of rabies virus infection, and is probably also involved in the mechanism of post-exposure rabies prophylaxis. Live-attenuated rabies virus vaccines (ERA, HEP, Kelev) induce a strong cytotoxic T lymphocyte (CTL)-mediated response following i.c. inoculation.
Hilary Koprowski +2 more
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Cell-mediated immunity plays a major role in pathogenicity of rabies virus infection, and is probably also involved in the mechanism of post-exposure rabies prophylaxis. Live-attenuated rabies virus vaccines (ERA, HEP, Kelev) induce a strong cytotoxic T lymphocyte (CTL)-mediated response following i.c. inoculation.
Hilary Koprowski +2 more
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1985
Rabies virus, in common with other members of the Rhabdoviridae, contains a single-stranded non-segmented RNA genome of negative polarity. Virus replication takes place in the cytoplasm of the infected cell and on infection the virus RNA is transcribed into five polyadenylated complementary monocystronic messenger (m) species.
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Rabies virus, in common with other members of the Rhabdoviridae, contains a single-stranded non-segmented RNA genome of negative polarity. Virus replication takes place in the cytoplasm of the infected cell and on infection the virus RNA is transcribed into five polyadenylated complementary monocystronic messenger (m) species.
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Interferon in Rabies Virus Infection
2011Rabies is among the longest known and most dangerous and feared infectious diseases for humans and animals and still is responsible for tenth of thousands of human deaths per year. The rabies virus (RABV) is a rather atypical member of the Rhabdoviridae family as it has completely adapted during evolution to warm-blooded hosts and is directly ...
Karl-Klaus Conzelmann, Martina Rieder
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The structural proteins of rabies virus
Comparative Immunology, Microbiology and Infectious Diseases, 1982The five structural proteins of rabies virus, L, G, N, M1 and M2 have been re-evaluated in light of recent results. It has been found that the M1 protein is associated with the N protein which together with the L protein and the RNA forms the nucleocapsid complex.
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Airborne Rabies Virus Isolation
Bulletin of the Wildlife Disease Association, 1968Airborne rabies virus was isolated from Frio Cave, Texas, using a mechanical air sampler. Several types of samplers have been used, but only an electrostatic precipitation device has collected measurable quantities of virus. Prior to this, the only known reported isolations of airborne rabies virus had occurred when susceptible animals were confined in
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