Results 71 to 80 of about 42,168 (252)

TED1 Promotes the Assembly of SCFD3‐D14‐D53 to Reinforce Strigolactone Signaling in Rice

Advanced Science, EarlyView.
This study identifies TED1 as a positive regulator of strigolactones (SL) signaling in rice. The ted1 mutants display dwarfism and increased tillering with significantly reduced SLs sensitivity. Through its longer C‐terminal region, TED1 interacts with D53 and D14 to promote the assembly of SCFD3‐D14‐D53, thereby facilitating the efficient ...
Sheng Luo, Chuanyin Wu, Miao Feng, Wenfan Luo, Rong Miao, Jinsheng Qian, Fan Wang, Chunlei Zhou, Bojuan Liu, Jiale Shao, Ziqi Xun, Yehui Xiong, Zhichao Zhao, Cailin Lei, Shanshan Zhu, Yulong Ren, Xin Wang, Xiuping Guo, Haiyang Wang, Zichao Li, Zhijun Cheng, Qibing Lin, Jianmin Wan   +22 more
wiley   +1 more source

Covalently Linked Peptides and Membrane Potential Enable CyaA Segment Translocation

Advanced Science, EarlyView.
Using a newly developed Droplet Interface Bilayer‐Pipette assay, the authors show that two segments of the CyaA toxin cross membranes by distinct mechanisms. One segment translocates spontaneously, whereas the translocation of the other depends on membrane potential.
Gaia Scilironi, Nicolas Carvalho, Jacinthe Frangieh, Corentin Léger, Dorothée Raoux‐Barbot, J. Iñaki Guijarro, Daniel Ladant, Sophie Cribier, Nicolas Rodriguez, Alexandre Chenal   +9 more
wiley   +1 more source

Video_5_The Rac-GEF Tiam1 controls integrin-dependent neutrophil responses.avi

, 2023
Rac GTPases are required for neutrophil adhesion and migration, and for the neutrophil effector responses that kill pathogens. These Rac-dependent functions are impaired when neutrophils lack the activators of Rac, Rac-GEFs from the Prex, Vav, and Dock ...
Melanie Stammers (17438187), Angeliki Malliri (2698933), Kirsti Hornigold (13336089), Rachael Walker (8204298), Anne Segonds-Pichon (3134094), Anna-Karin Johnsson (17438181), Polly A. Machin (13336098), Chiara Pantarelli (13336104), David Oxley (123444), Simon Walker (341179), Stephen A. Chetwynd (13336095), Heidi C. E. Welch (13336107), Priota Islam (17438184), Yoshinori Fukui (305480), Martin J. Baker (17438178), Laraine Crossland (13336101), Hanneke Okkenhaug (4021091)   +16 more
core   +1 more source

Targeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma

Advanced Science, EarlyView.
SOX2 upregulates KAT7 in glioma stem cells, where KAT7 deposits H3K14 acetylation at the RAC2 promoter to activate RAC2 transcription. RAC2‐GTP subsequently promotes PAK1/2/3 phosphorylation, increasing tricarboxylic acid cycle flux and mitochondrial respiration to support glioblastoma malignancy.
Jilong Liu, Yanfei Sun, Yuehua Zhu, Guangjing Mu, Jiazheng Wang, Liangliang Wang, Feihu Zhao, Zhimin Zhao, Jian Wang, Ying He, Zheng Jiang, Xingang Li, Mingzhi Han, Bin Huang   +13 more
wiley   +1 more source

Video_2_The Rac-GEF Tiam1 controls integrin-dependent neutrophil responses.avi

, 2023
Rac GTPases are required for neutrophil adhesion and migration, and for the neutrophil effector responses that kill pathogens. These Rac-dependent functions are impaired when neutrophils lack the activators of Rac, Rac-GEFs from the Prex, Vav, and Dock ...
Melanie Stammers (17438187), Angeliki Malliri (2698933), Kirsti Hornigold (13336089), Rachael Walker (8204298), Anne Segonds-Pichon (3134094), Anna-Karin Johnsson (17438181), Polly A. Machin (13336098), Chiara Pantarelli (13336104), David Oxley (123444), Simon Walker (341179), Stephen A. Chetwynd (13336095), Heidi C. E. Welch (13336107), Priota Islam (17438184), Yoshinori Fukui (305480), Martin J. Baker (17438178), Laraine Crossland (13336101), Hanneke Okkenhaug (4021091)   +16 more
core   +1 more source

Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9

Advanced Science, EarlyView.
In this study, we demonstrate that Zdhhc17, acting as a PAT, suppresses neuronal apoptosis and promotes axon regeneration after injury, thereby enhancing functional recovery following SCI. In this context, Kpna2 and Ipo9 serve as novel palmitoylation substrates of Zdhhc17, whose palmitoylation prevents the injury‐induced degradation of their proteins ...
Meixuan Chen, Huan Chen, Sining Ding, Fan Liu, Xiaofei Zheng, Yuan Wang, Ruitu Tian, Huan Li, Peilin Liu, Le Hu, Bin Liu, Limin Rong, Mangmang Li   +12 more
wiley   +1 more source

Effects of ractopamine hydrochloride on growth performance and carcass characteristics in wool and hair lambs

Italian Journal of Animal Science, 2013
This study aimed at evaluating the effects of ractopamine hydrochloride (RAC) on growth performance and carcass characteristics of wool and hair lambs.
Ángel M. Romero-Maya, José G. Herrera-Haro, Juan M.E. Pinos-Rodríguez, Juan C. García-López, Ricardo Bárcena-Gama, Sergio S. González-Muñoz   +5 more
doaj   +1 more source

Aluminum salen and salan complexes in the ring-opening polymerization of cyclic esters: Controlled immortal and copolymerization of rac-β-butyrolactone and rac-lactide [PDF]

, 2013
Aluminum-based salen and salan complexes mediate the ring-opening polymerization (ROP) of rac-β-butyrolactone (β-BL), rac-lactide, and ε-caprolactone. Al-salen and Al-salan complexes exhibit excellent control over the ROP of rac-β-butyrolactone, yielding
Andreas Decken, Cross, Edward D., Allan, Laura E. N., Allan, Laura E. N. (Author), Shaver, Michael P. (Author), Edward D. Cross, Laura E. N. Allan, Michael P. Shaver, Shaver, Michael P.; id_orcid, Decken, Andreas, Decken, Andreas (Author), Shaver, Michael P., Cross, Edward D. (Author)   +12 more
core   +1 more source

Video_6_The Rac-GEF Tiam1 controls integrin-dependent neutrophil responses.avi

, 2023
Rac GTPases are required for neutrophil adhesion and migration, and for the neutrophil effector responses that kill pathogens. These Rac-dependent functions are impaired when neutrophils lack the activators of Rac, Rac-GEFs from the Prex, Vav, and Dock ...
Melanie Stammers (17438187), Angeliki Malliri (2698933), Kirsti Hornigold (13336089), Rachael Walker (8204298), Anne Segonds-Pichon (3134094), Anna-Karin Johnsson (17438181), Polly A. Machin (13336098), Chiara Pantarelli (13336104), David Oxley (123444), Simon Walker (341179), Stephen A. Chetwynd (13336095), Heidi C. E. Welch (13336107), Priota Islam (17438184), Yoshinori Fukui (305480), Martin J. Baker (17438178), Laraine Crossland (13336101), Hanneke Okkenhaug (4021091)   +16 more
core   +1 more source

SPRED2 Negatively Regulates CD8+ T Cell‐Mediated Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
Sprouty‑related EVH1 domain containing 2 (SPRED2) restrains Ras/Raf/ERK signaling in CD8+ T cells. Host SPRED2 deficiency enhances T‐cell survival, cytotoxicity, and memory‐like phenotypes, reducing primary tumor growth and endpoint lung metastatic burden in breast cancer models.
Miao Tian, Teizo Yoshimura, Kun Zhao, Chunning Li, Tong Gao, Ziyi Wang, Masayoshi Fujisawa, Toshiaki Ohara, Akihiro Matsukawa   +8 more
wiley   +1 more source