Results 121 to 130 of about 457 (225)

Agonist‐specific conformational dynamics at the β2‐adrenoceptor dictate allosteric modulation of Gαs signalling and bronchodilation

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose β2‐adrenoceptor (β2AR) agonists are the cornerstone of asthma therapy and promote bronchodilation through Gαs signalling in airway smooth muscle (ASM), but their efficacy is limited by β‐arrestin‐mediated β2AR desensitization.
Sushrut D. Shah   +7 more
wiley   +1 more source

A unified formulation for home healthcare routing and scheduling problems

open access: yesInternational Transactions in Operational Research, EarlyView.
Abstract Home Healthcare is an essential component of healthcare systems, where caregivers visit patients' homes to deliver services. While presenting advantages with respect to institutional care, such as being cost‐effective and alleviating family burdens, it presents challenges in scheduling and routing caregivers efficiently.
Sara Ceschia   +7 more
wiley   +1 more source

Persistent Instability in Policy Debates: The Three‐Body Problem of Trade, Agriculture and the Environment

open access: yesJCMS: Journal of Common Market Studies, EarlyView.
Abstract Literature on policy debates often analyses cases involving either a single or two policy fields, which typically result in stable equilibria, manifesting either as outright rejection of policy proposals, successful institutional change or the entrenchment of divisions into a deadlock.
Laure Gosselin   +2 more
wiley   +1 more source

Harnessing Human Mobility Data for Applied Economic Research: Current Knowledge, Challenges, and Emerging Opportunities

open access: yesJournal of Economic Surveys, EarlyView.
ABSTRACT This paper reviews how large‐scale mobility data can enhance economic analyses, highlighting its contributions to understanding travel behavior, labor markets, social interactions, and health outcomes. We discuss its advantages over traditional mobility data sources, which include real‐time location information and fine spatial resolution ...
Cristina Connolly   +3 more
wiley   +1 more source

Synergies in Agricultural Biodiversity Conservation: Decomposing the Interaction Between Nature Parks and Agri‐Environment Schemes

open access: yesApplied Economic Perspectives and Policy, Volume 48, Issue 3, Page 634-652, July 2026.
ABSTRACT Understanding how policy instruments with overlapping goals interact is crucial for leveraging their synergies. This study explores the mechanisms for regional nature parks (a form of protected areas that impose no restrictions on agriculture) to enhance the adoption of biodiversity‐conserving agri‐environment schemes (AES) in Switzerland ...
Yanbing Wang   +3 more
wiley   +1 more source

MXenes in Advanced High‐Performance Energy Storage Technologies: Synthesis, Properties, Applications, and Challenges

open access: yesBattery Energy, Volume 5, Issue 4, July 2026.
MXene‐based electrodes are established as high‐performance electrochemical energy storage materials. Sustainable energy storage systems are enabled through biologically derived MXene synthesis routes. Electrochemical kinetics and charge storage are enhanced by biomimetic MXene structures.
Shajjadur Rahman Shajid   +3 more
wiley   +1 more source

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