Results 101 to 110 of about 7,135,260 (382)

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

open access: yesAdvanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du   +17 more
wiley   +1 more source

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

open access: yesAdvanced Science, EarlyView.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu   +6 more
wiley   +1 more source

Ultra Wide Swath Imaging With Multi-Channel SAR Systems [PDF]

open access: yes, 2008
Multi-channel radar systems allow for overcoming the inherent limitation of conventional synthetic aperture radar (SAR). An example is the combination of digital beamforming on receive in elevation with multi-aperture SAR signal reconstruction in azimuth
Bordoni, Federica   +4 more
core  

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

open access: yesAdvanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun   +11 more
wiley   +1 more source

High-Resolution Low-Sidelobe Waveform Design Based on HFPFM Coding Model for SAR

open access: yesSensors
Radar waveform design is an important approach to radar system performance enhancement. For a long time, synthetic aperture radar (SAR) systems have utilized linear frequency modulation (LFM) waveforms as transmitted signals and have relied on window ...
Yu Gao   +3 more
doaj   +1 more source

Development of a synthetic aperture radar design approach for wide-swath implementation [PDF]

open access: yes
The first phase of a study program to develop an advanced synthetic aperture radar design concept is presented. Attributes of particular importance for the system design include wide swath coverage, reduced power requirements, and versatility in the ...
Jean, B. R.
core   +1 more source

Recent Advances and Perspectives on Field‐Effect Transistors for Artificial Visual Neuromorphic Systems

open access: yesAdvanced Science, EarlyView.
This review presents a comprehensive overview of FET‐based visual neuromorphic systems, covering their semiconductor materials, core device architectures, and operating mechanisms. It further reviews their implementation in emulating biological visual functions, addresses current technological challenges, and outlines future development directions. The
Liu Yaqian   +11 more
wiley   +1 more source

Observation of the Earth by radar [PDF]

open access: yes
Techniques and applications of radar observation from Earth satellites are discussed. Images processing and analysis of these images are discussed. Also discussed is radar imaging from aircraft.
Elachi, C.
core   +1 more source

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

open access: yesAdvanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma   +15 more
wiley   +1 more source

A geoscience evaluation of multifrequency radar imagery of the Pisgah Crater area, California [PDF]

open access: yes
Comparison of multiband simultaneous radar imaging over geological test ...
Dellwig, L. F.
core   +1 more source

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