Results 161 to 170 of about 12,611,004 (335)

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

A Hybrid Hierarchical Framework for Quantifying Mechanical Markers in Atherosclerotic Disease Progression: A New Approach for Diagnosis and Risk Assessment

Advanced Science, EarlyView.
The mechanobiological basis of atherosclerotic progression and its contribution to spatial and temporal heterogeneity remain incompletely understood. Spatially resolved AFM measurements revealed that plaque formation and distinct regions (cap fibrosis, intimal fibrosis, and lipid‐rich core) exhibit heterogeneous elastic modulus and viscoelastic ...
Yidan Zhou, Zhuo Chang, Xianjun Wu, Sijie Wang, Yuzhi Zhang, Hao Zhang, Haoyu Xu, Ruining Peng, Zhe Wang, Huiyun Xu, Yu Liu, Guangkui Xu, Nu Zhang, Hui Yang   +13 more
wiley   +1 more source

Risk-Aware Resource Allocation Strategy for Target Tracking in a Cognitive Radar Network. [PDF]

Sensors (Basel)
Lee JY, Park J.
europepmc   +1 more source

qcGEM: A Graph‐Based Molecular Representation With Quantum Chemistry Awareness

Advanced Science, EarlyView.
In this work, we introduce qcGEM, a quantum‐chemistry‐aware graph‐based embedding of molecules that incorporates physical priors into molecular representation learning. Through a specially designed model architecture to adequately process quantum chemistry information as well as three‐dimensional molecular geometry, qcGEM provides a compact, physics ...
Haoyu Wang, Ziyan Zhang, Swee Hong Ng, Haipeng Gong   +3 more
wiley   +1 more source

AIMP-Based Power Allocation for Radar Network Tracking Under Countermeasures Environment. [PDF]

Sensors (Basel)
Xing X, Xu L, Nie L, Li X.
europepmc   +1 more source

Transformer‐Based Multitask Framework Integrating Habitat and Deep Learning for Predicting Early Disease Control and Survival in Immunotherapy‐Treated Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study developed ECOS‐Net, a transformer‐based multitask framework integrating CT‐derived habitat and 2.5D deep learning features to simultaneously predict early disease control and overall survival in hepatocellular carcinoma patients treated with immune checkpoint inhibitors.
Xiaona Fu, Yusheng Guo, Bingxin Gong, Jie Lou, Ning Wang, Xuejun Chen, Hongtao Hu, Rundong Wang, Xiaofang Guo, Shanmei Li, Yangyang Xie, Shichao Long, Mengsi Li, Shubo Pan, Wen Shen, Zhaogang Zhang, Zifang Song, Pengchen Liang, Xiaoyun Liang, Peng Sun, Guilin Zhang, Shanshan Jiang, Jinxiang Zhang, Lian Yang   +23 more
wiley   +1 more source

Hydrogel Phase Transition‐Driven Soft Gating Circumvents Debye Screening for Advanced Biosensing

Advanced Science, EarlyView.
A 3D soft gate utilizes a macroscopic hydrogel phase transition to effectively circumvent Debye screening in high‐salt environments. The intact matrix maximizes transmembrane ion flux via volumetric Donnan enrichment and superhydrophilicity. Target‐triggered network disassembly abolishes these effects, introducing a synergistic physical barrier.
Liu Shi, Zimeng Zhang, Bingheng Li, Yalei Gao, Ruirui Zhang, Zheying Mu, Jian Ni, Bing Bo, Genxi Li   +8 more
wiley   +1 more source

2D Vermiculite Nanosheets Encapsulated in Hydrogel Electrolyte for Shuttle‐Free and Dendrite‐Inhibited Zinc‐Iodine Batteries

Advanced Science, EarlyView.
A dual‐network hydrogel was prepared via a one‐pot method, incorporating vermiculite nanosheets as an additive. The negatively charged vermiculite nanosheets not only coordinate with zinc ions to facilitate Zn plating/stripping and suppress Zn dendrite growth, but also adsorb polyiodides to inhibit the shuttle effect, which significantly improves the ...
Yunlong Zhou, Chuanliang Wei, Huanyu Yang, Bin Li, Bo Yang, Jie Ren, Cheng Ye, Maofeng Zhang   +7 more
wiley   +1 more source

Classification of Human Micro-Doppler in a Radar Network

, 2013
IEEE Radar Conference (RADAR) -- APR 29-MAY 03, 2013 -- Ottawa, CANADAThe unique, bi-pedal motion of humans has been shown to generate a characteristic micro-Doppler signature in the time-frequency domain that can be used to discriminate humans from not ...
Tekeli, Burkan, Gurbuz, Sevgi Zubeyde, Yuksel, Melda, Gurbuz, Ali Cafer, Guldogan, Mehmet Burak   +4 more
core  

Foundation Model‐Enabled Pathology‐Informed MRI Model for Preoperative Prediction of Vessels Encapsulating Tumor Clusters in Resectable Hepatocellular Carcinoma: A Multicenter Retrospective Study

Advanced Science, EarlyView.
PIVOT uses pathology‐derived morphologic and vascular representations from postoperative H&E and CD34 whole‐slide images to guide model development, while clinical inference requires only preoperative multiparametric MRI. Across five centers, PIVOT enabled accurate preoperative assessment of vessels encapsulating tumor clusters, stratified patients by ...
Zhehan Shen, Wanmin Liu, Xiaoming Li, Wenjie Zou, Yiman Li, Jie Yuan, Yasen Yimit, Shihang Wang, Linhao Qu, Hui Dong, Wei Chen, Ningyang Jia, Peijun Wang   +12 more
wiley   +1 more source