Results 41 to 50 of about 71,417 (215)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Radial-to-femoral pressure gradient quantification in cardiac surgeryCentral MessagePerspective

JTCVS Open, 2021
Background: A radial-to-femoral pressure gradient (RFPG) can occur in roughly one-third of cardiac surgical patients. Such a gradient has been associated with smaller stature and potentially smaller radial artery diameter.
Vincent Bouchard-Dechêne, MD, FRCPC, Loay Kontar, MD, Pierre Couture, MD, FRCPC, Philippe Pérusse, MD, FRCPC, Sylvie Levesque, MSc, Yoan Lamarche, MD, MSc, André Y. Denault, MD, PhD, FRCPC, FASE, Antoine Rochon, MD, FRCPC, Alain Deschamps, MD, PhD, FRCPC, Georges Desjardins, MD, FRCPC, FASE, Nicolas Rousseau-Saine, MD, FRCPC, Jean-Sébastien Lebon, MD, FRCPC, Jennifer Cogan, MD, FRCPC, Marie-Eve Chamberland, MD, FRCPC, Meggie Raymond, MD, FRCPC, Athanase Courbe, MD, Marco Julien, MD, FRCPC, Christian Ayoub, MD, FRCPC, Maria Rosal Martins, MD, William Beaubien-Souligny, MD, FRCPC   +19 more
doaj   +1 more source

Biodegradable and Biocompatible Functional Polymers for Biomedical Applications

Advanced Functional Materials, EarlyView.
Biodegradable and biocompatible functional polymers integrate electrical, mechanical, and stimuli‐responsive functionalities while enabling programmed degradation under physiological conditions. This review introduces recent advances in conductive, shape‐memory, self‐healing, photocurable, and adhesive polymer systems, emphasizing material design ...
Won Bae Han, Shuvra Mondal, Sungkeun Han, Chan‐Hwi Eom, Venkata Ramesh Naganaboina, Suk‐Won Hwang   +5 more
wiley   +1 more source

The frequency of radial artery occlusion following cardiac catheterization with the use of transradial pneumatic compression band

BMC Research Notes, 2020
Objectives Radial artery occlusion is a silent complication of a transradial approach to cardiac catheterization that may complicate subsequent transradial procedures in patients undergoing cardiac catheterization.
Kashif Ali Hashmi, Zahid Iqbal, Atif Ali Hashmi, Maira Shoaib, Muhammad Irfan, Rabeet Khan, Nauman Ali, Amir khan, Muhammad M. Edhi   +8 more
doaj   +1 more source

Hydrogel Microtube Drug Carrier for Catheter‐Based Intravascular Therapy

Advanced Healthcare Materials, EarlyView.
This paper proposes hydrogel microtube carriers composed of barium alginate gel, enabling long‐term vascular retention without interrupting blood flow. Intravascular treatments have long been attracting attention for therapeutic efficacy, yet practical delivery methods remained unestablished.
Shota Sato, Hiroki Ohta, Naoki Takakura, Kentaro Kasa, Teppei Komatsu, Dai Kejia, Misato Yoshioka, Hirotaka James Okano, Hiroaki Onoe   +8 more
wiley   +1 more source

Biomimetic Vascular Scaffold with Seamless Electrospun Aligned Nanofiber Conduit and 3D‐Printed Coil Reinforcement

Advanced Healthcare Materials, EarlyView.
We introduce a new fabrication method that overcomes the current limitation of tubular gap electrospinning. We successfully fabricated a seamless hollow tube with fibers aligned along the longitudinal axis in diameters as small as 300 µm, and then reinforced it using 4‐axis 3D printing.
Seyed Aliakbar Hosseini Toopghara, Young‐Ook Hwang, In A Kim, Che‐I Hyun, Hochung Ryu, Won‐Jae Kim, Jeong‐Tae Koh, Hyun‐Pil Lim, Jin‐Ho Kang, Sang‐Won Park   +9 more
wiley   +1 more source

A cadaveric investigation of the radial artery origin and its anatomical variations

Translational Research in Anatomy
Introduction: According to standard anatomical description, the radial artery typically originates as one of two terminal branches of the brachial artery within the cubital fossa. Despite the common embryological process of the upper limb arteries, there
Aleisha J. Singh, Rohen Harrichandparsad, Lelika Lazarus   +2 more
doaj   +1 more source

Correlation between Doppler, Manual Morphometry, and Histopathology Based Morphometry of Radial Artery as a Conduit in Coronary Artery Bypass Grafting

Cardiology Research and Practice, 2016
Background. Long-term graft patency is the major factor impacting survival after coronary artery bypass grafting. Arteries are superior in this regard. Radial artery is considered the second best conduit after internal mammary artery.
Om Prakash Yadava, Vinod Sharma, Arvind Prakash, Vikas Ahlawat, Anirban Kundu, Bikram K. Mohanty, Rekha Mishra, Amit K. Dinda   +7 more
doaj   +1 more source

Impact of ischemic preconditioning on the radial artery vasomotor function

REC: Interventional Cardiology (English Ed.), 2023
To the Editor, Transcatheter radial access is the usual approach to perform a coronary angiography. The advantages of this access come with certain inherent limitations like radial spasm, endothelial dysfunction associated with the insertion of the ...
Eduardo Arroyo-Úcar, Borja Ibáñez Cabeza, Gonzalo Pizarro Sánchez   +2 more
doaj   +1 more source

Meniscus‐Guided Interfacial Ring‐by‐Ring Assembly for In Situ Fabrication of Tubular Hydrogels

Advanced Materials, EarlyView.
A tubular hydrogel fabrication method leveraging the meniscus effect at the oil‐water interface is presented. UV irradiation across the concave surface of the photocurable hydrogel precursor induces the formation of ring‐like hydrogel structures. Sequential ring‐by‐ring assembly within microchannels enables the construction of arteriole‐scale hydrogel ...
Yuki Kamiya, Yingzhe Wang, Keisuke Morishima   +2 more
wiley   +1 more source