Results 31 to 40 of about 40,111 (263)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

A Practical Operational Framework for Congestion Management in Active Distribution Networks Using Adaptive Radial–Mesh Reconfiguration

Energies
The increasing penetration of distributed energy resources (DERs), electric vehicles (EVs), and dynamic loads introduces significant operational challenges in modern distribution networks, including voltage violations, reverse power flows, and congestion.
Thunpisit Pothinun, Pannathon Rodkumnerd, Sirote Khunkitti, Paramet Wirasanti, Neville R. Watson   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Optimal protection coordination for directional overcurrent relays in radial distribution networks with inverter-based distributed energy resources

International Journal of Electrical Power & Energy Systems
The optimal setting of directional overcurrent relays ensures the reliable protection and fast fault clearance of radial distribution networks. However, the increasing proliferation of inverter-based distributed energy resources can result in protection ...
Jie Li, Jingtong Feng, Min Huang, Shenquan Liu, Gang Wang   +4 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

A Swarm Approach for Improving Voltage Profiles and Reduce Power Loss on Electrical Distribution Networks

IEEE Access, 2018
As a mean to provide reactive power compensation to radial distribution networks, capacitor banks are commonly installed within these electrical distribution systems.
Primitivo Diaz, Marco Perez-Cisneros, Erik Cuevas, Octavio Camarena, Fernando Abraham Fausto Martinez, Adrian Gonzalez   +5 more
doaj   +1 more source

On the Matricial Formulation of Iterative Sweep Power Flow for Radial and Meshed Distribution Networks with Guarantee of Convergence

Applied Sciences, 2020
This paper presents a general formulation of the classical iterative-sweep power flow, which is widely known as the backward–forward method. This formulation is performed by a branch-to-node incidence matrix with the main advantage that this approach can
Oscar Danilo Montoya, Walter Gil-González, Diego Armando Giral   +2 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Robust feeder reconfiguration in radial distribution networks [PDF]

International Journal of Electrical Power & Energy Systems, 2014
Distribution feeder reconfiguration has been an active field of research for many years. Some recent theoretical studies have highlighted the importance of smart reconfiguration for the operating conditions of such radial networks. In general, this problem has been tackled using a multi-objective formulation with simplified assumptions, in which the ...
Carlos Henrique Nogueira de Resende Barbosa, Marcus Henrique Soares Mendes, João Antônio de Vasconcelos   +2 more
openaire   +1 more source