Results 41 to 50 of about 35,706 (291)

Nonexistence of positive radial solutions for a problem with singular potential

Advances in Nonlinear Analysis, 2014
This article completes the picture in the study of positive radial solutions in the function space 𝒟1,2(ℝN)∩L2(ℝN,|x|-αdx)∩Lp(ℝN)${{\mathcal {D}^{1,2}({\mathbb {R}^N}) \cap L^2({{\mathbb {R}^N}, | x |^{-\alpha } dx})\cap L^p({\mathbb {R}^N})}}$ for the ...
Catrina Florin
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Separation structure of positive radial solutions of a semilinear elliptic equation in Rn

, 2003
This paper deals with the following inter-connected subjects: (i) Separation of positive radial solutions is studied for the elliptic equation Δu+K(|x|)up=0 in Rn. In case r−ℓK(r) is decreasing, with suitable decay rate, to a positive constant as r→∞ for
Bae, Soohyun, Soohyun Bae
core   +1 more source

Nonexistence of radial positive solutions for a nonpositone system in an annulus

Electronic Journal of Differential Equations, 2011
In this article we study the nonexistence of radial positive solutions for a nonpositone system in an annulus by using energy analysis and comparison methods.
Said Hakimi
doaj  

Strongly increasing solutions of cyclic systems of second order differential equations with power-type nonlinearities [PDF]

Opuscula Mathematica, 2015
We consider \(n\)-dimensional cyclic systems of second order differential equations \[(p_i(t)|x_{i}'|^{\alpha_i -1}x_{i}')' = q_{i}(t)|x_{i+1}|^{\beta_i-1}x_{i+1},\] \[\quad i = 1,\ldots,n, \quad (x_{n+1} = x_1) \tag{\(\ast\)}\] under the assumption that
Jaroslav Jaroš, Kusano Takaŝi
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Bounded and large radially symmetric solutions for some (p,q)-Laplacian stationary systems

Electronic Journal of Differential Equations, 2012
This article concerns radially symmetric positive solutions of second-order quasilinear elliptic systems. In terms of the growth of the variable potential functions, we establish conditions such that the solutions are either bounded or blow up at ...
Adel Ben Dkhil, Noureddine Zeddini
doaj