Results 51 to 60 of about 817,899 (281)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Spectroscopic Follow-up of Gaia Exoplanet Candidates: Impostor Binary Stars Invade the Gaia DR3 Astrometric Exoplanet Candidates

The Astronomical Journal, 2023
In this paper, we report on the follow-up of six potential exoplanets detected with Gaia astrometry and provide an overview of what is currently known about the nature of the entire Gaia astrometric exoplanet candidate sample, 72 systems in total.
Marcus L. Marcussen, Simon H. Albrecht
doaj   +1 more source

Flexibility Aggregation Perimeter for Ancillary Services in Radial Distribution Systems

IEEE Access, 2023
The flexibility provided by prosumers is recognized as a key element for the management of the electrical grids, in particular distribution grids, in the changing scenario of electricity generation and consumption.
Giovanni Mercurio Casolino, Arturo Losi
doaj   +1 more source

A universal velocity distribution of relaxed collisionless structures

, 2005
Several general trends have been identified for equilibrated, self-gravitating collisionless systems, such as density or anisotropy profiles. These are integrated quantities which naturally depend on the underlying velocity distribution function (VDF) of
Austin C G, Ben Moore, Cole S, Dehnen W McLaughlin D, Hansen S H, Hansen S H Stadel J, Joachim Stadel, Marcel Zemp, Merritt D, Stadel J, Steen H Hansen   +10 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Wide binaries without viable bound Newtonian orbits

Astronomy & Astrophysics
Context. Wide binaries offer a unique opportunity to test gravity in the low-acceleration regime, where deviations from Newtonian dynamics may appear. Aims.
Pasquini L., Saglia R., Patat F., Berni L., Bossini D., Magrini L., Ludwig H., Murphy M. T., de Medeiros J. R., Chanamé J.   +9 more
doaj   +1 more source

Radial Velocity Studies of Close Binary Stars.XIII

, 2008
Radial-velocity measurements and sine-curve fits to the orbital radial velocity variations are presented for ten close binary systems: EG Cep,V1191 Cyg, V1003 Her, BD+7_3142, V357 Peg, V407 Peg, V1123 Tau, V1128 Tau, HH UMa, and PY Vir. While most of the
, Archie de Ridder, Chochol, Cox, Duerbeck, Evgenij Liokumovich, Heide DeBond, Høg, J. R. Thomson, Kaluzny, Kreiner, Krysztof Kaminski, Maciejewski, Maciejewski, Mason, Matt Rock, Mayer, Piotr Ligeza, Pojmanski, Pribulla, Pribulla, Pribulla, Pribulla, Rucinski, Rucinski, Rucinski, Skrutskie, Slavek M. Rucinski, Stefan W. Mochnacki, Strohmeier, Theodor Pribulla, Toomas Karmo, Waldemar Ogłoza, Wenxian Lu, Wils, Yasarsoy, Özdarcan   +36 more
core   +1 more source

On the GBDT version of the B\"acklund-Darboux transformation and its applications to the linear and nonlinear equations and Weyl theory [PDF]

, 2009
A general theorem on the GBDT version of the B\"acklund-Darboux transformation for systems rationally depending on the spectral parameter is treated and its applications to nonlinear equations are given.
Sakhnovich, Alexander
core   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Optimal siting of capacitors in radial distribution network using Whale Optimization Algorithm

Alexandria Engineering Journal, 2017
In present days, continuous effort is being made in bringing down the line losses of the electrical distribution networks. Therefore proper allocation of capacitors is of utmost importance because, it will help in reducing the line losses and maintaining
D.B. Prakash, C. Lakshminarayana
doaj   +1 more source