Results 91 to 100 of about 128,924 (308)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Retrieval of surface temperature by remote sensing [PDF]
A simple procedure and computer program were developed for retrieving the surface temperature from the measurement of upwelling infrared radiance in a single spectral region in the atmosphere.
Gupta, S. K., Tiwari, S. N.
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Biophysical climate mitigation potential of coniferous forests in temperate ecosystems of South Tyrol [PDF]
GeoreviewForests affect climate parameters through impacts from biochemical and biophysical processes. However, the effects of the coniferous stands on hydrological setting in temperate regions have received little attention.
Polina LEMENKOVA
doaj +1 more source
Remote sensing investigations of wetland biomass and productivity for global biosystems research [PDF]
The relationship between spectral radiance and plant canopy biomass was studied in wetlands. Spectroradiometer data was gathered on Thematic Mapper wavebands 3, 4, and 5, and correlated with canopy and edaphic factors determined by harvesting.
Klemas, V.
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Ground support data from July 10 to July 29, 1978, for HCMM thermal satellite data of the Powder River Basin, Wyoming [PDF]
Radiometric and meteorological data acquired at three ground stations located approximately 150 km apart in the Powder River Basin, Wyoming, are summarized.
Hummer-Miller, S. +2 more
core +1 more source
Insights into a long life without cancer: The case of the bowhead whale
Molecular Oncology, EarlyView.Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley +1 more source
Radiometric responsivity determination for Feature Identification and Location Experiment (FILE) flown on space shuttle mission [PDF]
A procedure was developed to obtain the radiometric (radiance) responsivity of the Feature Identification and Local Experiment (FILE) instrument in preparation for its flight on Space Shuttle Mission 41-G (November 1984).
Bullock, G. F. +4 more
core +1 more source