Results 71 to 80 of about 33,254 (214)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
AtmosphereWe analyze the evolution of atmospheric and surface physical properties over the region of the Earth observed by the Meteosat Second Generation (MSG) satellites during the period 2005–2024. Long-term changes are detected in the observed radiances, with a
José I. Prieto-Fernández +1 more
doaj +1 more source
Estimation of the sky radiance [PDF]
Scientific Technical Review, 2019 For the infrared prefilter model there was a need for testing the sky radiation and defining its fluctuations within the zone of neighborhood area for the current frame and tests of repeatability.
Knežević Dragan +3 more
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
SensorsNighttime light (NTL) data is widely used to monitor urban development, economic activity and population distribution, supporting socio-economic analysis and sustainable development planning. SDGSAT-1 NTL data, with its multiple bands and high resolution,
Jinke Liu +4 more
doaj +1 more source
Nighttime Reflectance Generation in the Visible Band of Satellites
Remote Sensing, 2019 Visible (VIS) bands, such as the 0.675 μm band in geostationary satellite remote sensing, have played an important role in monitoring and analyzing weather and climate change during the past few decades with coarse spatial and high temporal ...
Kimoon Kim +7 more
doaj +1 more source
Estimating the irradiance spectrum from measurements in a limited number of spectral bands
, 2006 Accurate measurement and characterisation of fluctuations in the irradiance environment is important for many areas of optical remote sensing. This paper describes a method of estimating spectral irradiance over the region 400 – 1000 nm from the radiance
Milton, E.J., Rollin, E.M.
core +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Radiance Uncertainty Characterisation to Facilitate Climate Data Record Creation
Remote Sensing, 2019 The uncertainty in a climate data records (CDRs) derived from Earth observations in part derives from the propagated uncertainty in the radiance record (the fundamental climate data record, FCDR) from which the geophysical estimates in the CDR are ...
Christopher J. Merchant +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source