Results 191 to 200 of about 221,736 (298)

Radiotherapy for low grade gliomas in children with neurofibromatosis type 1: when there is no other choice. Case Report. [PDF]

Front Oncol
Castellano-Damaso S, Vazquez-Gomez F, Perez-Somarriba M, Muñoz-Fernandez M, Montero-Feijoo M, Solís-Muñiz I, Lassaletta A.   +6 more
europepmc   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

The tumor microenvironment as a key regulator of radiotherapy response. [PDF]

Front Immunol
Ma X, Zhang N.
europepmc   +1 more source

Quantitative Mass Spectrometry‐Based Biodistribution of Monoclonal Antibodies: An Alternative to Radio‐Biodistribution

Advanced Science, EarlyView.
Monoclonal antibodies are powerful anticancer therapeutics targeting tumor‐associated antigens. Mass spectrometry enables precise and accurate quantification of mAbs in tumor plasma and healthy organs. Unlike ligand binding assay and radioactivity, mass spectrometry does not suffer from matrix effects and labelling artefacts while facilitating method ...
Domenico Ravazza, Sheila Dakhel Plaza, Samuele Cazzamalli, Andrea Ciamarone, Andrea Galbiati, Riccardo Stucchi, Frederik Peissert, Emanuele Puca, Dario Neri, Ettore Gilardoni   +9 more
wiley   +1 more source

Pulmonary Complications of Cancer Therapy: Clinical Presentations, Imaging Patterns, and Management Strategies. [PDF]

Medicina (Kaunas)
Zafar B, Haque T, Tan M, Singh R, Bashoura L, Sheshadri A, Azhar M, Faiz SA.   +7 more
europepmc   +1 more source

Biophysical aspects of radiation carcinogenesis [PDF]

, 1975
A Cole, AH Sparrow, AM Kellerer, AM Kellerer, AM Kellerer, AM Kellerer, C Borek, CJ Shellabarger, CJ Shellabarger, DE Lea, DJ Hughes, E Schmid, EJ Hall, HH Rossi, HH Rossi, HH Rossi, HH Smith, HH Vogel, HH Withers, ICRU, ICRU, J Brenot, JG Brewen, JL Bateman, JRK Savage, K Sax, K Sax, MT Biola, RL Bach, S Wolf, SB Field, T Ishimaru, VP Bond, WC Dewey, WK Sinclair   +34 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Competitive cell transplantation in rat mammary tissue and its use for radiation-induced cell competition and tumor clonality assays. [PDF]

J Radiat Res
Nagata K, Nishimura-Yano Y, Hosoki A, Kudo KI, Daino K, Nishimura M, Imaoka T.   +6 more
europepmc   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Multidisciplinary Surgical Management of Radiation-Induced Colorectal Stricture and Pelvic Adhesions: A Case Report. [PDF]

Cureus
Khan TA, Swami J.
europepmc   +1 more source